Syed Suhail Andrabi1, Shruti Vishnoi1, Medha Kaushik1, Khina Parveen1, Heena Tabassum2, Mohd Akram3, Suhel Parvez1. 1. Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India. 2. Division of Biomedical Sciences, Indian Council of Medical Research, Ministry of Health and Family Welfare, Govt. of India, V. Ramalingaswamy Bhawan, New Delhi, India. 3. Department of Tahaffuzi wa Samaji Tibb, School of Unani Medical Education and Research, Jamia Hamdard, New Delhi, India. Electronic address: makram@jamiahamdard.ac.in.
Abstract
BACKGROUND: Melatonin is a neurohormone that is linked to the pathogenesis of schizophrenia. The aim of this study was to assess the potential of melatonin in attenuating MK-801 induced schizophrenia-like behavioral and brain neurotoxicity markers. METHODS: Swiss albino mice were assigned into three groups (n = 6). Animals were administered MK-801 (1 mg/kg/mL, i.p.). MK-801 treated animals were supplemented with melatonin (10 mg/kg/1 mL i.p.) 10 min prior to MK-801 injection. The relative degrees of modulation of induced behaviors by melatonin were assessed in the open field, elevated plus maze, grip strength and rota rod. The changes in neurotoxicity enzymes and neuronal activity (c-fos) were demonstrated in this study. RESULTS: MK-801 injection effected normal open-field behaviors, c-fos expression, motor coordination and muscular strength. Melatonin was able to reduce the histological changes in the prefrontal cortex of mice brain. CONCLUSION: Our data demonstrated that the treatment with melatonin attenuates the schizophrenic like symptoms in the mice having a protective effect on prefrontal cortex region of brain by mitigating the alteration of neurotoxicity markers. The protective effect of the treatment was shown to reduced elevation of AChE, c-fos expression and histopathological alterations.
BACKGROUND:Melatonin is a neurohormone that is linked to the pathogenesis of schizophrenia. The aim of this study was to assess the potential of melatonin in attenuating MK-801 induced schizophrenia-like behavioral and brain neurotoxicity markers. METHODS: Swiss albino mice were assigned into three groups (n = 6). Animals were administered MK-801 (1 mg/kg/mL, i.p.). MK-801 treated animals were supplemented with melatonin (10 mg/kg/1 mL i.p.) 10 min prior to MK-801 injection. The relative degrees of modulation of induced behaviors by melatonin were assessed in the open field, elevated plus maze, grip strength and rota rod. The changes in neurotoxicity enzymes and neuronal activity (c-fos) were demonstrated in this study. RESULTS:MK-801 injection effected normal open-field behaviors, c-fos expression, motor coordination and muscular strength. Melatonin was able to reduce the histological changes in the prefrontal cortex of mice brain. CONCLUSION: Our data demonstrated that the treatment with melatonin attenuates the schizophrenic like symptoms in the mice having a protective effect on prefrontal cortex region of brain by mitigating the alteration of neurotoxicity markers. The protective effect of the treatment was shown to reduced elevation of AChE, c-fos expression and histopathological alterations.
Authors: Marcelo Gomes Granja; Letícia Pires Alves; Marina Leardini-Tristão; Michelle Edelman Saul; Letícia Coelho Bortoni; Flávia Maciel de Moraes; Erica Camila Ferreira; Bianca Portugal Tavares de Moraes; Victória Zerboni da Silva; Adrielle Ferreira Ribeiro Dos Santos; Adriana Ribeiro Silva; Cassiano Felippe Gonçalves-de-Albuquerque; Victorio Bambini-Junior; Andrew S Weyrich; Matthew T Rondina; Guy A Zimmerman; Hugo Caire de Castro-Faria-Neto Journal: J Neuroinflammation Date: 2021-02-25 Impact factor: 8.322
Authors: Alexandre González-Rodríguez; José Haba-Rubio; Judith Usall; Mentxu Natividad; Virginia Soria; Javier Labad; José A Monreal Journal: Clocks Sleep Date: 2022-02-15