Immunosenescence. Clinical and pharmacologic considerations.

The effect of aging on the immune response is highly variable. Many individuals appear to maintain adequate immunologic function throughout life, whereas others have severely depressed immunologic responses accounting for disease activity. Both cellular- and humoral-mediated responses may be abnormal in the elderly. Aberrant function of immunoregulatory cells, effector T cells, and antibody-producing B cells contribute to poor immunity in the aged. Immunoenhancement in the elderly by pharmacologic agents appears promising. Several agents have been demonstrated to improve immune responses when administered to aging animals and humans. Although these studies are encouraging, it is not known if enhancement of immune responses in the elderly will be associated with clinical benefits. This issue must still be examined.