Literature DB >> 31599366

Bilirubin Safeguards Cardiorenal and Metabolic Diseases: a Protective Role in Health.

Terry D Hinds1, David E Stec2.   

Abstract

PURPOSE OF REVIEW: To discuss recent advances indicating that bilirubin safeguards against cardiorenal and metabolic diseases. RECENT
FINDINGS: Several investigations from human patient populations and experimental animal models have shown that bilirubin improves cardiorenal and metabolic dysfunction. The latest studies found an entirely new function of bilirubin suggesting that it acts as a hormone signaling molecule capable of activating nuclear receptors for burning fat, which may explain several of its protective actions. This review highlights the current findings (within the last 3 years) regarding cardiorenal and metabolic protective effects of bilirubin and the latest mechanism(s) that may be mediating these effects.

Entities:  

Keywords:  Biliverdin reductase; Hypertension; Kidney; Metabolic syndrome; PPARalpha

Mesh：

Substances：

Year:  2019        PMID： 31599366      PMCID： PMC6938163          DOI： 10.1007/s11906-019-0994-z

Source DB:  PubMed          Journal:  Curr Hypertens Rep        ISSN： 1522-6417            Impact factor:   5.369


  61 in total

Review 1.  Biliverdin reductase and bilirubin in hepatic disease.

Authors:  Lauren Weaver; Abdul-Rizaq Hamoud; David E Stec; Terry D Hinds
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2018-03-01       Impact factor: 4.052

2.  Serum bilirubin levels are negatively associated with diabetic retinopathy in patients with type 1 diabetes and normal renal function.

Authors:  Tomislav Bulum; Martina Tomić; Lea Duvnjak
Journal:  Int Ophthalmol       Date:  2017-05-18       Impact factor: 2.031

Review 3.  Bilirubin, a Cardiometabolic Signaling Molecule.

Authors:  Terry D Hinds; David E Stec
Journal:  Hypertension       Date:  2018-10       Impact factor: 10.190

4.  Relationship Between Total Serum Bilirubin Levels and Carotid and Femoral Atherosclerosis in Familial Dyslipidemia.

Authors:  Antonio J Amor; Emilio Ortega; Verónica Perea; Montserrat Cofán; Aleix Sala-Vila; Isabel Nuñez; Rosa Gilabert; Emilio Ros
Journal:  Arterioscler Thromb Vasc Biol       Date:  2017-10-26       Impact factor: 8.311

5.  Relation of High Serum Bilirubin to Short-Term Mortality Following a Myocardial Infarction Complicated by Left Ventricular Systolic Dysfunction (from the High-Risk Myocardial Infarction Database Initiative).

Authors:  Zied Frikha; João Pedro Ferreira; Erwan Bozec; John J V McMurray; Bertram Pitt; Kenneth Dickstein; Patrick Rossignol; Faiez Zannad; Nicolas Girerd
Journal:  Am J Cardiol       Date:  2018-02-05       Impact factor: 2.778

6.  Bilirubin acts as an endogenous regulator of inflammation by disrupting adhesion molecule-mediated leukocyte migration.

Authors:  Megan E Vogel; Stephen D Zucker
Journal:  Inflamm Cell Signal       Date:  2016-02-15

7.  Bilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARγ Levels.

Authors:  Jinfeng Liu; Huansheng Dong; Yong Zhang; Mingjun Cao; Lili Song; Qingjie Pan; Andrew Bulmer; David B Adams; Xiao Dong; Hongjun Wang
Journal:  Sci Rep       Date:  2015-05-28       Impact factor: 4.379

8.  Relationship between serum bilirubin concentrations and diabetic nephropathy in Shanghai Han's patients with type 1 diabetes mellitus.

Authors:  Xu Li; Lei Zhang; Haibing Chen; Kaifeng Guo; Haoyong Yu; Jian Zhou; Ming Li; Qing Li; Lianxi Li; Jun Yin; Fang Liu; Yuqian Bao; Junfeng Han; Weiping Jia
Journal:  BMC Nephrol       Date:  2017-03-31       Impact factor: 2.388

9.  Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade.

Authors:  Luca Vanella; Komal Sodhi; Dong Hyun Kim; Nitin Puri; Mani Maheshwari; Terry D Hinds; Lars Bellner; Dov Goldstein; Stephen J Peterson; Joseph I Shapiro; Nader G Abraham
Journal:  Stem Cell Res Ther       Date:  2013-03-12       Impact factor: 6.832

Review 10.  Glucuronidation and UGT isozymes in bladder: new targets for the treatment of uroepithelial carcinomas?

Authors:  Vikram L Sundararaghavan; Puneet Sindhwani; Terry D Hinds
Journal:  Oncotarget       Date:  2017-01-10
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  16 in total

1.  Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor α.

Authors:  Darren M Gordon; Kari L Neifer; Abdul-Rizaq Ali Hamoud; Charles F Hawk; Andrea L Nestor-Kalinoski; Scott A Miruzzi; Michael P Morran; Samuel O Adeosun; Jeffrey G Sarver; Paul W Erhardt; Robert E McCullumsmith; David E Stec; Terry D Hinds
Journal:  J Biol Chem       Date:  2020-05-13       Impact factor: 5.157

Review 2.  Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications.

Authors:  John A McClung; Lior Levy; Victor Garcia; David E Stec; Stephen J Peterson; Nader G Abraham
Journal:  Pharmacol Ther       Date:  2021-09-06       Impact factor: 12.310

Review 3.  Novel Function for Bilirubin as a Metabolic Signaling Molecule: Implications for Kidney Diseases.

Authors:  David E Stec; Claudio Tiribelli; Olufunto O Badmus; Terry D Hinds
Journal:  Kidney360       Date:  2022-03-25

Review 4.  Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin.

Authors:  Alessio Nocentini; Alessandro Bonardi; Simone Pratesi; Paola Gratteri; Carlo Dani; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

Review 5.  Bilirubin as a metabolic hormone: the physiological relevance of low levels.

Authors:  Justin F Creeden; Darren M Gordon; David E Stec; Terry D Hinds
Journal:  Am J Physiol Endocrinol Metab       Date:  2020-12-07       Impact factor: 4.310

6.  Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice.

Authors:  David E Stec; Darren M Gordon; Andrea L Nestor-Kalinoski; Matthew C Donald; Zachary L Mitchell; Justin F Creeden; Terry D Hinds
Journal:  Biomolecules       Date:  2020-03-02

Review 7.  OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention.

Authors:  Stephen J Peterson; Abu Choudhary; Amardeep K Kalsi; Shuyang Zhao; Ragin Alex; Nader G Abraham
Journal:  Diagnostics (Basel)       Date:  2020-11-20

8.  Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.

Authors:  Terry D Hinds; Zachary A Kipp; Mei Xu; Frederique B Yiannikouris; Andrew J Morris; Donald F Stec; Walter Wahli; David E Stec
Journal:  Cells       Date:  2021-12-21       Impact factor: 6.600

9.  Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1.

Authors:  Terry D Hinds; Justin F Creeden; Darren M Gordon; Adam C Spegele; Steven L Britton; Lauren G Koch; David E Stec
Journal:  Antioxidants (Basel)       Date:  2020-09-19

10.  Identification of Binding Regions of Bilirubin in the Ligand-Binding Pocket of the Peroxisome Proliferator-Activated Receptor-A (PPARalpha).

Authors:  Darren M Gordon; Stephen H Hong; Zachary A Kipp; Terry D Hinds
Journal:  Molecules       Date:  2021-05-17       Impact factor: 4.411
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