| Literature DB >> 31599282 |
Ping Bai1, Hsiao-Ying Wey2, Debasis Patnaik3, Xiaoxia Lu4, Yu Lan2, Johanna Rokka2, Fiedler Stephanie2, Stephen J Haggarty3, Changning Wang2.
Abstract
Here, we report the development of novel PET radiotracer ([11C]CW22) of BET proteins. In vivo imaging results in rodents and nonhuman primates (NHP) demonstrate that [11C]CW22 has excellent brain uptake, good specificity, good selectivity, suitable metabolism, appropriate kinetics and distribution in the brain. Our studies demonstrated that [11C]CW22 exhibits ideal properties as a PET imaging probe of BET proteins for further validation.Entities:
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Year: 2019 PMID： 31599282 DOI： 10.1039/c9cc06734e
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222