Julie M Thompson1,2, Stephanie M Eick3, Cody Dailey1,4, Ariella P Dale5, Mansi Mehta1, Anjali Nair1, José F Cordero1, Michael Welton1. 1. Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 30605 Athens, GA, USA. 2. College of Veterinary Medicine, University of Georgia, 30602 Athens, GA, USA. 3. Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology, and Reproductive Services, University of California, San Francisco, 94158 San Francisco, CA, USA. 4. Odum School of Ecology, University of Georgia, 30602 Athens, GA, USA. 5. Colorado Department of Public Health & Environment, 80246 Denver, CO, USA.
Abstract
BACKGROUND: Pregnancy-associated malaria (PAM) has been associated with adverse pregnancy outcomes like preterm birth (PTB) and low birthweight (LBW), which are among the leading causes of infant mortality globally. Rates of PTB and LBW are high in countries with a high burden of malaria. PAM may be a contributing factor to PTB and LBW, but is not well understood. METHODS: We conducted a systematic review and meta-analysis of studies examining the relationship between PAM and PTB or LBW using PubMed. The title and abstract of all studies were screened by two reviewers, and the full text of selected studies was reviewed to ensure they met inclusion criteria. Information regarding study characteristics and of PTB and LBW births among women with and without PAM was abstracted for included studies. RESULTS: Our search terms yielded 2237 articles, of which 18 met our final inclusion criteria. Eight studies examined associations between PAM and PTB, and 10 examined associations between PAM and LBW (population size ranging from 35 to 9956 women). The overall risk of LBW was 63% higher among women with PAM compared with women without PAM (95% CI = 1.48-1.80) and the risk of PTB was 23% higher among women with PAM compared with women without PAM (95% CI = 1.07-1.41). CONCLUSIONS: These results indicate that infection with PAM is associated with PTB and LBW. Further understanding of the pathogenesis of disease and the immunologic changes that occur during pregnancy is essential for reducing the disproportional effects this disease has on this vulnerable population.
BACKGROUND: Pregnancy-associated malaria (PAM) has been associated with adverse pregnancy outcomes like preterm birth (PTB) and low birthweight (LBW), which are among the leading causes of infantmortality globally. Rates of PTB and LBW are high in countries with a high burden of malaria. PAM may be a contributing factor to PTB and LBW, but is not well understood. METHODS: We conducted a systematic review and meta-analysis of studies examining the relationship between PAM and PTB or LBW using PubMed. The title and abstract of all studies were screened by two reviewers, and the full text of selected studies was reviewed to ensure they met inclusion criteria. Information regarding study characteristics and of PTB and LBW births among women with and without PAM was abstracted for included studies. RESULTS: Our search terms yielded 2237 articles, of which 18 met our final inclusion criteria. Eight studies examined associations between PAM and PTB, and 10 examined associations between PAM and LBW (population size ranging from 35 to 9956 women). The overall risk of LBW was 63% higher among women with PAM compared with women without PAM (95% CI = 1.48-1.80) and the risk of PTB was 23% higher among women with PAM compared with women without PAM (95% CI = 1.07-1.41). CONCLUSIONS: These results indicate that infection with PAM is associated with PTB and LBW. Further understanding of the pathogenesis of disease and the immunologic changes that occur during pregnancy is essential for reducing the disproportional effects this disease has on this vulnerable population.
Authors: Louise G Grunnet; Ib C Bygbjerg; Theonest K Mutabingwa; Fanny Lajeunesse-Trempe; Jannie Nielsen; Christentze Schmiegelow; Allan A Vaag; Kaushik Ramaiya; Dirk L Christensen Journal: BMJ Open Diabetes Res Care Date: 2022-04
Authors: Makoto Saito; Rashid Mansoor; Kalynn Kennon; Anupkumar R Anvikar; Elizabeth A Ashley; Daniel Chandramohan; Lauren M Cohee; Umberto D'Alessandro; Blaise Genton; Mary Ellen Gilder; Elizabeth Juma; Linda Kalilani-Phiri; Irene Kuepfer; Miriam K Laufer; Khin Maung Lwin; Steven R Meshnick; Dominic Mosha; Atis Muehlenbachs; Victor Mwapasa; Norah Mwebaza; Michael Nambozi; Jean-Louis A Ndiaye; François Nosten; Myaing Nyunt; Bernhards Ogutu; Sunil Parikh; Moo Kho Paw; Aung Pyae Phyo; Mupawjay Pimanpanarak; Patrice Piola; Marcus J Rijken; Kanlaya Sriprawat; Harry K Tagbor; Joel Tarning; Halidou Tinto; Innocent Valéa; Neena Valecha; Nicholas J White; Jacher Wiladphaingern; Kasia Stepniewska; Rose McGready; Philippe J Guérin Journal: BMC Med Date: 2020-06-02 Impact factor: 8.775