Kyoung Min Lee1,2, Tae-Woo Kim1,3, Eun Ji Lee1,3, Michaël J A Girard4,5, Jean Martial Mari6, Robert N Weinreb7. 1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. 2. Department of Ophthalmology, Seoul National University Boramae Medical Center, Seoul, Korea. 3. Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea. 4. Department of Bioengineering, National University of Singapore, Singapore. 5. Singapore Eye Research Institute, Singapore. 6. Université de la Polynésie française, Tahiti, French Polynesia. 7. Hamilton Glaucoma Center, Shiley Eye Institute, and Viterbi Family Department of Ophthalmology, University of California, San Diego, California, United States.
Abstract
Purpose: To investigate whether corneal biomechanical properties are associated with the lamina cribrosa (LC) curvature in eyes with primary open angle glaucoma (POAG). Methods: Corneal biomechanical properties and LC curvature were assessed in 65 treatment-naïve POAG patients. Corneal biomechanical properties, including corneal hysteresis (CH), corneal resistance factor (CRF), and corneal-compensated intraocular pressure (IOPcc), were measured using an ocular response analyzer (ORA; Reichert Ophthalmic Instruments). LC curvature was assessed by measuring the LC curvature index (LCCI) on B-scan images obtained using spectral-domain optical coherence tomography (OCT). The LCCI was determined by measuring LC curve depth on the anterior LC surface and the width of the reference line. Results: The LCCI was correlated with CH (P = 0.001), CRF (P = 0.012) and IOPcc (P = 0.001) in the univariate analysis. To adjust multicollinearity, principal component analysis was performed, and multivariate regression analyses were conducted using one variable from each component. The larger LCCI was associated with larger IOPcc (P < 0.001), smaller CRF (P = 0.001) and smaller CH (P < 0.001). Conclusions: Lower CH was associated with a more posteriorly curved LC in treatment naïve POAG patients. This finding may provide a basic explanation for the reported association between CH and an increased risk for glaucoma development and progression, and support a potential value of CH for risk assessment for glaucoma.
Purpose: To investigate whether corneal biomechanical properties are associated with the lamina cribrosa (LC) curvature in eyes with primary open angle glaucoma (POAG). Methods:Corneal biomechanical properties and LC curvature were assessed in 65 treatment-naïve POAG patients. Corneal biomechanical properties, including corneal hysteresis (CH), corneal resistance factor (CRF), and corneal-compensated intraocular pressure (IOPcc), were measured using an ocular response analyzer (ORA; Reichert Ophthalmic Instruments). LC curvature was assessed by measuring the LC curvature index (LCCI) on B-scan images obtained using spectral-domain optical coherence tomography (OCT). The LCCI was determined by measuring LC curve depth on the anterior LC surface and the width of the reference line. Results: The LCCI was correlated with CH (P = 0.001), CRF (P = 0.012) and IOPcc (P = 0.001) in the univariate analysis. To adjust multicollinearity, principal component analysis was performed, and multivariate regression analyses were conducted using one variable from each component. The larger LCCI was associated with larger IOPcc (P < 0.001), smaller CRF (P = 0.001) and smaller CH (P < 0.001). Conclusions: Lower CH was associated with a more posteriorly curved LC in treatment naïve POAG patients. This finding may provide a basic explanation for the reported association between CH and an increased risk for glaucoma development and progression, and support a potential value of CH for risk assessment for glaucoma.