Selçuk Sayilir1, Neşat Çullu2, Gönen Mengi3, Timur Ekiz4. 1. Department of Physical Medicine and Rehabilitation, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey. 2. Department of Radiology, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey. 3. Department of Rheumatology, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey. 4. Department of Physical Medicine and Rehabilitation, Dermancan Medical Center, Adana, Turkey.
Abstract
Objectives: This study aims to evaluate olfactory bulb (OB) volume in patients with rheumatoid arthritis (RA) using magnetic resonance imaging. Patients and methods: In this retrospective and case-control study, OB volumes of 37 RA patients (6 males, 31 females; mean age 48.6±10.8 years; range, 18 to 65 years) were compared with those of 36 healthy control subjects (5 males, 31 females; mean age 46.5±6.9 years; range, 22 to 62 years). OB images were gained with a protocol of 256×256 matrix and a 24-cm field of view, repetition time=5000 milliseconds (TR 5000 msec), echo time=130 milliseconds (TE 130 msec), number of excitations=2 (NEX 2) and a 5 mm slice thickness. OB volume was computed with the aid of the above images using three dimensional views. The surface of each slice area was calculated in mm2 and all surfaces were added and multiplied by front-back length to obtain a volume in mm3. Results: Left (70.5±14.4 vs. 91.1±12.2 mm3), right (73.9±15.1 vs. 91.2±12.4 mm3), and total (144.5±27.4 vs. 182.8±21.5 mm3) OB volumes were significantly lower in the RA group than in the control group (all p<0.05). Conclusion: Patients with RA may be under risk of decreased OB volumes and related impaired odor functions which might affect the quality of life and activities of daily living adversely.
Objectives: This study aims to evaluate olfactory bulb (OB) volume in patients with rheumatoid arthritis (RA) using magnetic resonance imaging. Patients and methods: In this retrospective and case-control study, OB volumes of 37 RApatients (6 males, 31 females; mean age 48.6±10.8 years; range, 18 to 65 years) were compared with those of 36 healthy control subjects (5 males, 31 females; mean age 46.5±6.9 years; range, 22 to 62 years). OB images were gained with a protocol of 256×256 matrix and a 24-cm field of view, repetition time=5000 milliseconds (TR 5000 msec), echo time=130 milliseconds (TE 130 msec), number of excitations=2 (NEX 2) and a 5 mm slice thickness. OB volume was computed with the aid of the above images using three dimensional views. The surface of each slice area was calculated in mm2 and all surfaces were added and multiplied by front-back length to obtain a volume in mm3. Results: Left (70.5±14.4 vs. 91.1±12.2 mm3), right (73.9±15.1 vs. 91.2±12.4 mm3), and total (144.5±27.4 vs. 182.8±21.5 mm3) OB volumes were significantly lower in the RA group than in the control group (all p<0.05). Conclusion:Patients with RA may be under risk of decreased OB volumes and related impaired odor functions which might affect the quality of life and activities of daily living adversely.
Authors: Paul J Moberg; Vidyulata Kamath; Dana M Marchetto; Monica E Calkins; Richard L Doty; Chang-Gyu Hahn; Karin E Borgmann-Winter; Christian G Kohler; Raquel E Gur; Bruce I Turetsky Journal: Schizophr Bull Date: 2013-05-02 Impact factor: 9.306
Authors: Fidias E Leon-Sarmiento; Edgardo A Bayona; Jaime Bayona-Prieto; Allen Osman; Richard L Doty Journal: PLoS One Date: 2012-10-17 Impact factor: 3.240