Literature DB >> 31598400

Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer.

Xiaoli Zhang1, Qing Fang2, Yiming Ma1, Shuangmei Zou2, Qian Liu3, Hongying Wang1.   

Abstract

MYO10 is an actin-based motor protein and correlates with cancer metastasis. However, the regulation of MYO10 by tumor microenvironment is unknown. In the current study, we found that the expression of protease activated receptor 2 (PAR2) was highly correlated with that of MYO10 in colorectal carcinoma (CRC) specimens. Both MYO10 and PAR2 were up-regulated in lymph node metastasis group compared with non-metastasis group. Activation of PAR2 significantly induced cell migration through the up-regulation of MYO10, which was mediated by repression of miR-204 in multiple cell lines. Interestingly, it was observed that tryptase was highly expressed in adjacent tissue around primary tumor of CRC. Furthermore, tryptase stimulated cell migration and up-regulated MYO10 expression through a PAR2-dependent manner. Taken together, our findings showed that PAR2 enhanced the expression of MYO10 through the repression of miR-204. PAR2 mediated tryptase-induced cell migration and might contribute to the invasion of cancer cells at the edge of tumor. AJCR
Copyright © 2019.

Entities:  

Keywords:  Cancer metastasis; MYO10; PAR2; miR-204; tryptase

Year:  2019        PMID： 31598400      PMCID： PMC6780659     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  27 in total

Review 1.  Targeting proteinase-activated receptors: therapeutic potential and challenges.

Authors:  Rithwik Ramachandran; Farshid Noorbakhsh; Kathryn Defea; Morley D Hollenberg
Journal:  Nat Rev Drug Discov       Date:  2012-01-03       Impact factor: 84.694

Review 2.  The lung microenvironment: an important regulator of tumour growth and metastasis.

Authors:  Nasser K Altorki; Geoffrey J Markowitz; Dingcheng Gao; Jeffrey L Port; Ashish Saxena; Brendon Stiles; Timothy McGraw; Vivek Mittal
Journal:  Nat Rev Cancer       Date:  2019-01       Impact factor: 60.716

3.  Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b.

Authors:  Lan Yang; Yiming Ma; Wenxiao Han; Weiwei Li; Liang Cui; Xinhua Zhao; Yantao Tian; Zhixiang Zhou; Wengong Wang; Hongying Wang
Journal:  J Biol Chem       Date:  2015-09-09       Impact factor: 5.157

4.  Identification of molecular subtypes of glioblastoma by gene expression profiling.

Authors:  Paul S Mischel; Ruty Shai; Tao Shi; Steve Horvath; Kan V Lu; Gheeyoung Choe; David Seligson; Thomas J Kremen; Aarno Palotie; Linda M Liau; Timothy F Cloughesy; Stanley F Nelson
Journal:  Oncogene       Date:  2003-04-17       Impact factor: 9.867

5.  TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.

Authors:  Daniel P Hall; Nicholas G Cost; Shailaja Hegde; Emily Kellner; Olga Mikhaylova; Yiwen Stratton; Birgit Ehmer; William A Abplanalp; Raghav Pandey; Jacek Biesiada; Christian Harteneck; David R Plas; Jarek Meller; Maria F Czyzyk-Krzeska
Journal:  Cancer Cell       Date:  2014-11-10       Impact factor: 31.743

6.  Classification of pediatric acute lymphoblastic leukemia by gene expression profiling.

Authors:  Mary E Ross; Xiaodong Zhou; Guangchun Song; Sheila A Shurtleff; Kevin Girtman; W Kent Williams; Hsi-Che Liu; Rami Mahfouz; Susana C Raimondi; Noel Lenny; Anami Patel; James R Downing
Journal:  Blood       Date:  2003-05-01       Impact factor: 22.113

7.  Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia.

Authors:  Marie Schoumacher; Robert D Goldman; Daniel Louvard; Danijela M Vignjevic
Journal:  J Cell Biol       Date:  2010-04-26       Impact factor: 10.539

8.  MicroRNA-205 Mediates Proteinase-Activated Receptor 2 (PAR2) -Promoted Cancer Cell Migration.

Authors:  Xu Yang; Lan Yang; Yiming Ma; Xinhua Zhao; Hongying Wang
Journal:  Cancer Invest       Date:  2017-10-09       Impact factor: 2.176

9.  Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.

Authors:  Antti Arjonen; Riina Kaukonen; Elina Mattila; Pegah Rouhi; Gunilla Högnäs; Harri Sihto; Bryan W Miller; Jennifer P Morton; Elmar Bucher; Pekka Taimen; Reetta Virtakoivu; Yihai Cao; Owen J Sansom; Heikki Joensuu; Johanna Ivaska
Journal:  J Clin Invest       Date:  2014-03       Impact factor: 14.808

10.  Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis.

Authors:  R Cao; J Chen; X Zhang; Y Zhai; X Qing; W Xing; L Zhang; Y S Malik; H Yu; X Zhu
Journal:  Br J Cancer       Date:  2014-06-12       Impact factor: 7.640
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  4 in total

1.  Protease profile of normal and neoplastic mast cells in the human bone marrow with special emphasis on systemic mastocytosis.

Authors:  Dmitri Atiakshin; Igor Buchwalow; Peter Horny; Markus Tiemann
Journal:  Histochem Cell Biol       Date:  2021-01-25       Impact factor: 4.304

2.  PAR2 Promoter Hypomethylation Regulates PAR2 Gene Expression and Promotes Lung Adenocarcinoma Cell Progression.

Authors:  Kuan Wu; Lei Xu; Ling Cheng
Journal:  Comput Math Methods Med       Date:  2021-04-15       Impact factor: 2.238

3.  SIO: A Spatioimageomics Pipeline to Identify Prognostic Biomarkers Associated with the Ovarian Tumor Microenvironment.

Authors:  Ying Zhu; Sammy Ferri-Borgogno; Jianting Sheng; Tsz-Lun Yeung; Jared K Burks; Paola Cappello; Amir A Jazaeri; Jae-Hoon Kim; Gwan Hee Han; Michael J Birrer; Samuel C Mok; Stephen T C Wong
Journal:  Cancers (Basel)       Date:  2021-04-08       Impact factor: 6.639

Review 4.  Myosin Motors: Novel Regulators and Therapeutic Targets in Colorectal Cancer.

Authors:  Nayden G Naydenov; Susana Lechuga; Emina H Huang; Andrei I Ivanov
Journal:  Cancers (Basel)       Date:  2021-02-11       Impact factor: 6.639
  4 in total

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