| Literature DB >> 31598392 |
Ahmed Elaileh1, Ashish Saharia1, Lucy Potter1, Flavio Baio1, Afnan Ghafel2, Maen Abdelrahim1, Kirk Heyne1.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer mortality among men and women in the United States. Its incidence has been on the rise, with a projected two-fold increase by 2030. PDAC carries a poor prognosis due to a lack of effective screening tools, limited understanding of pathophysiology, and ineffective treatment modalities. Recently, there has been a revolution in the world of oncology with the advent of novel treatments to combat this disease. However, the 5-year survival of PDAC remains unchanged at a dismal 8%. The aim of this review is to bring together several studies and identify various recent modalities that have been promising in treating PDAC. AJCREntities:
Keywords: BRCA; Pancreatic cancer; cancer vaccine; check point inhibitor; hypoxia induced resistance; immunotherapy; targeted therapy
Year: 2019 PMID: 31598392 PMCID: PMC6780661
Source DB: PubMed Journal: Am J Cancer Res ISSN: 2156-6976 Impact factor: 6.166