Literature DB >> 31598392

Promising new treatments for pancreatic cancer in the era of targeted and immune therapies.

Ahmed Elaileh1, Ashish Saharia1, Lucy Potter1, Flavio Baio1, Afnan Ghafel2, Maen Abdelrahim1, Kirk Heyne1.   

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer mortality among men and women in the United States. Its incidence has been on the rise, with a projected two-fold increase by 2030. PDAC carries a poor prognosis due to a lack of effective screening tools, limited understanding of pathophysiology, and ineffective treatment modalities. Recently, there has been a revolution in the world of oncology with the advent of novel treatments to combat this disease. However, the 5-year survival of PDAC remains unchanged at a dismal 8%. The aim of this review is to bring together several studies and identify various recent modalities that have been promising in treating PDAC. AJCR
Copyright © 2019.

Entities:  

Keywords:  BRCA; Pancreatic cancer; cancer vaccine; check point inhibitor; hypoxia induced resistance; immunotherapy; targeted therapy

Year:  2019        PMID: 31598392      PMCID: PMC6780661     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN: 2156-6976            Impact factor:   6.166


  140 in total

1.  Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.

Authors:  Dung T Le; Andrea Wang-Gillam; Vincent Picozzi; Tim F Greten; Todd Crocenzi; Gregory Springett; Michael Morse; Herbert Zeh; Deirdre Cohen; Robert L Fine; Beth Onners; Jennifer N Uram; Daniel A Laheru; Eric R Lutz; Sara Solt; Aimee Luck Murphy; Justin Skoble; Ed Lemmens; John Grous; Thomas Dubensky; Dirk G Brockstedt; Elizabeth M Jaffee
Journal:  J Clin Oncol       Date:  2015-01-12       Impact factor: 44.544

2.  The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress.

Authors:  Amy S Lee
Journal:  Methods       Date:  2005-04       Impact factor: 3.608

3.  Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer.

Authors:  Dung T Le; Eric Lutz; Jennifer N Uram; Elizabeth A Sugar; Beth Onners; Sara Solt; Lei Zheng; Luis A Diaz; Ross C Donehower; Elizabeth M Jaffee; Daniel A Laheru
Journal:  J Immunother       Date:  2013-09       Impact factor: 4.456

4.  Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation.

Authors:  Dan Laheru; Eric Lutz; James Burke; Barbara Biedrzycki; Sara Solt; Beth Onners; Irena Tartakovsky; John Nemunaitis; Dung Le; Elizabeth Sugar; Kristen Hege; Elizabeth Jaffee
Journal:  Clin Cancer Res       Date:  2008-03-01       Impact factor: 12.531

Review 5.  Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.

Authors:  Robert D Schreiber; Lloyd J Old; Mark J Smyth
Journal:  Science       Date:  2011-03-25       Impact factor: 47.728

6.  REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Authors:  J Ross Chapman; Inger Brandsma; Guotai Xu; Jingsong Yuan; Martin Mistrik; Peter Bouwman; Jirina Bartkova; Ewa Gogola; Daniël Warmerdam; Marco Barazas; Janneke E Jaspers; Kenji Watanabe; Mark Pieterse; Ariena Kersbergen; Wendy Sol; Patrick H N Celie; Philip C Schouten; Bram van den Broek; Ahmed Salman; Marja Nieuwland; Iris de Rink; Jorma de Ronde; Kees Jalink; Simon J Boulton; Junjie Chen; Dik C van Gent; Jiri Bartek; Jos Jonkers; Piet Borst; Sven Rottenberg
Journal:  Nature       Date:  2015-03-23       Impact factor: 49.962

7.  The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression.

Authors:  Kay-Dietrich Wagner; Julien Cherfils-Vicini; Naoki Hosen; Peter Hohenstein; Eric Gilson; Nicholas D Hastie; Jean-François Michiels; Nicole Wagner
Journal:  Nat Commun       Date:  2014-12-16       Impact factor: 14.919

8.  Primary malignant melanoma of the cervix: Report of 14 cases and review of literature.

Authors:  Guangwen Yuan; Lingying Wu; Bin Li; Jusheng An
Journal:  Oncotarget       Date:  2017-04-18

9.  Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies.

Authors:  Milind M Javle; Rachna T Shroff; Henry Xiong; Gauri A Varadhachary; David Fogelman; Shrikanth A Reddy; Darren Davis; Yujian Zhang; Robert A Wolff; James L Abbruzzese
Journal:  BMC Cancer       Date:  2010-07-14       Impact factor: 4.430

Review 10.  Genetics and biology of pancreatic ductal adenocarcinoma.

Authors:  Haoqiang Ying; Prasenjit Dey; Wantong Yao; Alec C Kimmelman; Giulio F Draetta; Anirban Maitra; Ronald A DePinho
Journal:  Genes Dev       Date:  2016-02-15       Impact factor: 11.361

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  7 in total

1.  Identification of MBOAT2 as an Unfavorable Biomarker Correlated with KRAS Activation and Reduced CD8+ T-Cell Infiltration in Pancreatic Cancer.

Authors:  Zhenchong Li; Hongkai Zhuang; Xinming Chen; Yue Zhang; Zuyi Ma; Shujie Wang; Qian Yan; Zixuan Zhou; Shanzhou Huang; Chuanzhao Zhang; Baohua Hou
Journal:  J Oncol       Date:  2022-05-04       Impact factor: 4.501

Review 2.  The Effects of Capsaicin on Gastrointestinal Cancers.

Authors:  George Denis Alexandru Popescu; Cristian Scheau; Ioana Anca Badarau; Mihai-Daniel Dumitrache; Ana Caruntu; Andreea-Elena Scheau; Daniel Octavian Costache; Raluca Simona Costache; Carolina Constantin; Monica Neagu; Constantin Caruntu
Journal:  Molecules       Date:  2020-12-28       Impact factor: 4.411

Review 3.  Pancreatic Cancer and Cellular Senescence: Tumor Microenvironment under the Spotlight.

Authors:  Michela Cortesi; Michele Zanoni; Francesca Pirini; Maria Maddalena Tumedei; Sara Ravaioli; Ilario Giovanni Rapposelli; Giovanni Luca Frassineti; Sara Bravaccini
Journal:  Int J Mol Sci       Date:  2021-12-27       Impact factor: 5.923

4.  Prognostic Stratification Based on HIF-1 Signaling for Evaluating Hypoxic Status and Immune Infiltration in Pancreatic Ductal Adenocarcinomas.

Authors:  Hongkai Zhuang; Shujie Wang; Bo Chen; Zedan Zhang; Zuyi Ma; Zhenchong Li; Chunsheng Liu; Zixuan Zhou; Yuanfeng Gong; Shanzhou Huang; Baohua Hou; Yajin Chen; Chuanzhao Zhang
Journal:  Front Immunol       Date:  2021-12-03       Impact factor: 7.561

5.  Identification of hub genes and their novel diagnostic and prognostic significance in pancreatic adenocarcinoma.

Authors:  Duo Zuo; Yongzi Chen; Xinwei Zhang; Zhuozhi Wang; Wenna Jiang; Fan Tang; Runfen Cheng; Yi Sun; Lu Sun; Li Ren; Rui Liu
Journal:  Cancer Biol Med       Date:  2021-08-17       Impact factor: 5.347

6.  GTF2IRD1 overexpression promotes tumor progression and correlates with less CD8+ T cells infiltration in pancreatic cancer.

Authors:  Chuanzhao Zhang; Baohua Hou; Hongkai Zhuang
Journal:  Biosci Rep       Date:  2020-09-30       Impact factor: 3.840

7.  Identification of LIPH as an unfavorable biomarkers correlated with immune suppression or evasion in pancreatic cancer based on RNA-seq.

Authors:  Hongkai Zhuang; Xinming Chen; Ying Wang; Shanzhou Huang; Bo Chen; Chuanzhao Zhang; Baohua Hou
Journal:  Cancer Immunol Immunother       Date:  2021-07-19       Impact factor: 6.968

  7 in total

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