Literature DB >> 31597593

Microglia as Dynamic Cellular Mediators of Brain Function.

Elizabeth C Wright-Jin1, David H Gutmann2.   

Abstract

Originally hypothesized to function solely as immunologic responders within the central nervous system (CNS), emerging evidence has revealed that microglia have more complex roles in normal brain development and in the context of disease. In health, microglia influence neural progenitor fate decisions, astrocyte activation, neuronal homeostasis, and synaptogenesis. In the setting of brain disease, including autism, brain tumors, and neurodegenerative disorders, microglia undergo substantial morphological, molecular, and functional changes, which establish new biological states relevant to disease pathogenesis and progression. In this review, we discuss the function of microglia in health and disease and outline a conceptual framework for elucidating their specific contributions to nervous system pathobiology.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  brain; central nervous system; glioma; macrophage; microglia; precision medicine

Mesh：

Substances：

Year:  2019        PMID： 31597593      PMCID： PMC6829057          DOI： 10.1016/j.molmed.2019.08.013

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  125 in total

1.  Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathway.

Authors:  Xian-zong Ye; Sen-lin Xu; Yan-hong Xin; Shi-cang Yu; Yi-fang Ping; Lu Chen; Hua-liang Xiao; Bin Wang; Liang Yi; Qing-liang Wang; Xue-feng Jiang; Lang Yang; Peng Zhang; Cheng Qian; You-hong Cui; Xia Zhang; Xiu-wu Bian
Journal:  J Immunol       Date:  2012-06-04       Impact factor: 5.422

2.  Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes.

Authors:  Ruth M Barrientos; Matthew G Frank; Nicole Y Crysdale; Timothy R Chapman; Jared T Ahrendsen; Heidi E W Day; Serge Campeau; Linda R Watkins; Susan L Patterson; Steven F Maier
Journal:  J Neurosci       Date:  2011-08-10       Impact factor: 6.167

3.  Approaching a Scientific Consensus on the Association between Allergies and Glioma Risk: A Report from the Glioma International Case-Control Study.

Authors:  E Susan Amirian; Renke Zhou; Margaret R Wrensch; Sara H Olson; Michael E Scheurer; Dora Il'yasova; Daniel Lachance; Georgina N Armstrong; Lucie S McCoy; Ching C Lau; Elizabeth B Claus; Jill S Barnholtz-Sloan; Joellen Schildkraut; Francis Ali-Osman; Siegal Sadetzki; Christoffer Johansen; Richard S Houlston; Robert B Jenkins; Jonine L Bernstein; Ryan T Merrell; Faith G Davis; Rose Lai; Sanjay Shete; Christopher I Amos; Beatrice S Melin; Melissa L Bondy
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-02       Impact factor: 4.254

Review 4.  Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases.

Authors:  Yu Tang; Weidong Le
Journal:  Mol Neurobiol       Date:  2015-01-20       Impact factor: 5.590

5.  Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing.

Authors:  Qingyun Li; Zuolin Cheng; Lu Zhou; Spyros Darmanis; Norma F Neff; Jennifer Okamoto; Gunsagar Gulati; Mariko L Bennett; Lu O Sun; Laura E Clarke; Julia Marschallinger; Guoqiang Yu; Stephen R Quake; Tony Wyss-Coray; Ben A Barres
Journal:  Neuron       Date:  2018-12-31       Impact factor: 17.173

6.  Associations between allergic conditions and pediatric brain tumors in Neurofibromatosis type 1.

Authors:  Bree Porcelli; Nancy L Zoellner; Salmafatima S Abadin; David H Gutmann; Kimberly J Johnson
Journal:  Fam Cancer       Date:  2016-04       Impact factor: 2.375

7.  Neonatal rat microglia derived from different brain regions have distinct activation responses.

Authors:  Aaron Y Lai; Kamaldeep S Dhami; Comfort D Dibal; Kathryn G Todd
Journal:  Neuron Glia Biol       Date:  2011-02

8.  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:  Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg
Journal:  Nat Genet       Date:  2011-04-03       Impact factor: 38.330

9.  Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.

Authors:  Frank Szulzewsky; Andreas Pelz; Xi Feng; Michael Synowitz; Darko Markovic; Thomas Langmann; Inge R Holtman; Xi Wang; Bart J L Eggen; Hendrikus W G M Boddeke; Dolores Hambardzumyan; Susanne A Wolf; Helmut Kettenmann
Journal:  PLoS One       Date:  2015-02-06       Impact factor: 3.240

Review 10.  Microbiome-microglia connections via the gut-brain axis.

Authors:  Reem Abdel-Haq; Johannes C M Schlachetzki; Christopher K Glass; Sarkis K Mazmanian
Journal:  J Exp Med       Date:  2018-11-01       Impact factor: 14.307
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  30 in total

1.  A brain-enriched lncRNA shields cancer cells from immune-mediated killing for metastatic colonization in the brain.

Authors:  Weiguang Liu; Peng Sun; Lingling Xia; Xilin He; Zhengmiao Xia; Yehong Huang; Wenzhuo Liu; Lulu Li; Liming Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2022-05-26       Impact factor: 12.779

2.  Effects of Ischemia on the Migratory Capacity of Microglia Along Collagen Microcontact Prints on Organotypic Mouse Cortex Brain Slices.

Authors:  Katharina Steiner; Christian Humpel
Journal:  Front Cell Neurosci       Date:  2022-06-16       Impact factor: 6.147

3.  Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice.

Authors:  Lu Zheng; Yi Wang; Bin Shao; Huijuan Zhou; Xing Li; Cai Zhang; Ning Sun; Jing Shi
Journal:  Neurosci Bull       Date:  2022-03-30       Impact factor: 5.271

4.  Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells.

Authors:  Nobuhito Murai; Maisam Mitalipova; Rudolf Jaenisch
Journal:  Eur J Neurosci       Date:  2020-09-14       Impact factor: 3.386

Review 5.  Sex Differences in Glioblastoma Immunotherapy Response.

Authors:  Juyeun Lee; Kristen Kay; Katie Troike; Manmeet S Ahluwalia; Justin D Lathia
Journal:  Neuromolecular Med       Date:  2021-04-17       Impact factor: 3.843

Review 6.  The roles of microglia in neural remodeling during retinal degeneration.

Authors:  Hui Gao; Xiaona Huang; Juncai He; Ting Zou; Xuan Chen; Haiwei Xu
Journal:  Histol Histopathol       Date:  2021-10-25       Impact factor: 2.303

7.  Characterization of neurological disease progression in a canine model of CLN5 neuronal ceroid lipofuscinosis.

Authors:  Elizabeth J Meiman; Grace Robinson Kick; Cheryl A Jensen; Joan R Coates; Martin L Katz
Journal:  Dev Neurobiol       Date:  2022-04-28       Impact factor: 3.102

Review 8.  T lymphocytes as dynamic regulators of glioma pathobiology.

Authors:  Elizabeth C Cordell; Mahmoud S Alghamri; Maria G Castro; David H Gutmann
Journal:  Neuro Oncol       Date:  2022-10-03       Impact factor: 13.029

Review 9.  Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs.

Authors:  Walter H Moos; Douglas V Faller; Ioannis P Glavas; David N Harpp; Iphigenia Kanara; Anastasios N Mavrakis; Julie Pernokas; Mark Pernokas; Carl A Pinkert; Whitney R Powers; Konstantina Sampani; Kosta Steliou; Demetrios G Vavvas; Robert J Zamboni; Krishna Kodukula; Xiaohong Chen
Journal:  Biores Open Access       Date:  2020-03-31

10.  MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome-like Behaviors in Mice.

Authors:  Adam J Harrington; Catherine M Bridges; Stefano Berto; Kayla Blankenship; Jennifer Y Cho; Ahlem Assali; Benjamin M Siemsen; Hannah W Moore; Evgeny Tsvetkov; Acadia Thielking; Genevieve Konopka; David B Everman; Michael D Scofield; Steven A Skinner; Christopher W Cowan
Journal:  Biol Psychiatry       Date:  2020-03-31       Impact factor: 13.382
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