BACKGROUND: Little is known about the neural substrates of suicide risk in mood disorders. Improving the identification of biomarkers of suicide risk, as indicated by a history of suicide-related behavior (SB), could lead to more targeted treatments to reduce risk. METHODS: Participants were 18 young adults with a mood disorder with a history of SB (as indicated by endorsing a past suicide attempt), 60 with a mood disorder with a history of suicidal ideation (SI) but not SB, 52 with a mood disorder with no history of SI or SB (MD), and 82 healthy comparison participants (HC). Resting-state functional connectivity within and between intrinsic neural networks, including cognitive control network (CCN), salience and emotion network (SEN), and default mode network (DMN), was compared between groups. RESULTS: Several fronto-parietal regions (k > 57, p < 0.005) were identified in which individuals with SB demonstrated distinct patterns of connectivity within (in the CCN) and across networks (CCN-SEN and CCN-DMN). Connectivity with some of these same regions also distinguished the SB group when participants were re-scanned after 1-4 months. Extracted data defined SB group membership with good accuracy, sensitivity, and specificity (79-88%). CONCLUSIONS: These results suggest that individuals with a history of SB in the context of mood disorders may show reliably distinct patterns of intrinsic network connectivity, even when compared to those with mood disorders without SB. Resting-state fMRI is a promising tool for identifying subtypes of patients with mood disorders who may be at risk for suicidal behavior.
BACKGROUND: Little is known about the neural substrates of suicide risk in mood disorders. Improving the identification of biomarkers of suicide risk, as indicated by a history of suicide-related behavior (SB), could lead to more targeted treatments to reduce risk. METHODS:Participants were 18 young adults with a mood disorder with a history of SB (as indicated by endorsing a past suicide attempt), 60 with a mood disorder with a history of suicidal ideation (SI) but not SB, 52 with a mood disorder with no history of SI or SB (MD), and 82 healthy comparison participants (HC). Resting-state functional connectivity within and between intrinsic neural networks, including cognitive control network (CCN), salience and emotion network (SEN), and default mode network (DMN), was compared between groups. RESULTS: Several fronto-parietal regions (k > 57, p < 0.005) were identified in which individuals with SB demonstrated distinct patterns of connectivity within (in the CCN) and across networks (CCN-SEN and CCN-DMN). Connectivity with some of these same regions also distinguished the SB group when participants were re-scanned after 1-4 months. Extracted data defined SB group membership with good accuracy, sensitivity, and specificity (79-88%). CONCLUSIONS: These results suggest that individuals with a history of SB in the context of mood disorders may show reliably distinct patterns of intrinsic network connectivity, even when compared to those with mood disorders without SB. Resting-state fMRI is a promising tool for identifying subtypes of patients with mood disorders who may be at risk for suicidal behavior.
Authors: Kimberly A Van Orden; Tracy K Witte; Kelly C Cukrowicz; Scott R Braithwaite; Edward A Selby; Thomas E Joiner Journal: Psychol Rev Date: 2010-04 Impact factor: 8.934
Authors: Hang Joon Jo; Stephen J Gotts; Richard C Reynolds; Peter A Bandettini; Alex Martin; Robert W Cox; Ziad S Saad Journal: J Appl Math Date: 2013-05-21
Authors: Taylor A Burke; Samantha L Connolly; Jessica L Hamilton; Jonathan P Stange; Lyn Y Abramson; Lauren B Alloy Journal: J Abnorm Child Psychol Date: 2016-08
Authors: B P Chang; J C Franklin; J D Ribeiro; K R Fox; K H Bentley; E M Kleiman; M K Nock Journal: Transl Psychiatry Date: 2016-09-13 Impact factor: 6.222
Authors: Scott A Langenecker; Mindy Westlund Schreiner; Leah R Thomas; Katie L Bessette; Sophia R DelDonno; Lisanne M Jenkins; Rebecca E Easter; Jonathan P Stange; Stephanie L Pocius; Alina Dillahunt; Tiffany M Love; K Luan Phan; Vincent Koppelmans; Martin Paulus; Martin A Lindquist; Brian Caffo; Brian J Mickey; Robert C Welsh Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2021-07-13