Caitlin Dreisbach1,2, Stephanie Prescott1,3, Jeanne Alhusen1. 1. School of Nursing, University of Virginia, Charlottesville, VA, USA. 2. Data Science Institute, University of Virginia, Charlottesville, VA, USA. 3. Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Abstract
BACKGROUND: Maternal obesity is a well-known risk factor for significant obstetric and neonatal complications. The influence of the gastrointestinal microbiome in the setting of maternal obesity during pregnancy is less understood. The purpose of this systematic review is to synthesize the literature on the relationships between maternal obesity and excessive gestational weight gain (EGWG) and the composition of maternal and child gastrointestinal microbiomes. METHOD: We searched CINHAL, OVID Medline, Web of Science, and PubMed for relevant literature using medical subject heading terms related to obesity, pregnancy, and the gastrointestinal microbiome. We assessed 249 articles for potential inclusion using the preferred reporting items for systematic review and meta-analyses framework and deemed 11 articles as relevant for this review. RESULTS: Maternal obesity was associated with significant microbial changes in both maternal and infant fecal microbiome biospecimens including increases in Bacteroidetes, Firmicutes, and the Actinobacteria phyla and decreases in Bifidobacteria. However, inconsistencies in uniform taxonomic results across all studies mean that evidence of specific microbial associations with obesity and EGWG is inconclusive. CONCLUSION: Our findings suggest that both maternal and child gastrointestinal microbiome composition is altered in the setting of maternal obesity and EGWG during pregnancy. Future microbiome studies should concentrate on the investigation of metagenomic sequencing to elucidate microbial function rather than solely taxonomic composition. More diverse populations of mothers should be sampled to address health disparities and adverse outcomes of underrepresented populations. Finally, analytic pipelines should be standardized across studies to aid in reproducibility.
BACKGROUND:Maternal obesity is a well-known risk factor for significant obstetric and neonatal complications. The influence of the gastrointestinal microbiome in the setting of maternal obesity during pregnancy is less understood. The purpose of this systematic review is to synthesize the literature on the relationships between maternal obesity and excessive gestational weight gain (EGWG) and the composition of maternal and childgastrointestinal microbiomes. METHOD: We searched CINHAL, OVID Medline, Web of Science, and PubMed for relevant literature using medical subject heading terms related to obesity, pregnancy, and the gastrointestinal microbiome. We assessed 249 articles for potential inclusion using the preferred reporting items for systematic review and meta-analyses framework and deemed 11 articles as relevant for this review. RESULTS:Maternal obesity was associated with significant microbial changes in both maternal and infant fecal microbiome biospecimens including increases in Bacteroidetes, Firmicutes, and the Actinobacteria phyla and decreases in Bifidobacteria. However, inconsistencies in uniform taxonomic results across all studies mean that evidence of specific microbial associations with obesity and EGWG is inconclusive. CONCLUSION: Our findings suggest that both maternal and childgastrointestinal microbiome composition is altered in the setting of maternal obesity and EGWG during pregnancy. Future microbiome studies should concentrate on the investigation of metagenomic sequencing to elucidate microbial function rather than solely taxonomic composition. More diverse populations of mothers should be sampled to address health disparities and adverse outcomes of underrepresented populations. Finally, analytic pipelines should be standardized across studies to aid in reproducibility.
Authors: Fredrik Bäckhed; Hao Ding; Ting Wang; Lora V Hooper; Gou Young Koh; Andras Nagy; Clay F Semenkovich; Jeffrey I Gordon Journal: Proc Natl Acad Sci U S A Date: 2004-10-25 Impact factor: 11.205
Authors: Luisa F Gomez-Arango; Helen L Barrett; H David McIntyre; Leonie K Callaway; Mark Morrison; Marloes Dekker Nitert Journal: Diabetes Date: 2016-05-23 Impact factor: 9.461
Authors: Juan Miguel Rodríguez; Kiera Murphy; Catherine Stanton; R Paul Ross; Olivia I Kober; Nathalie Juge; Ekaterina Avershina; Knut Rudi; Arjan Narbad; Maria C Jenmalm; Julian R Marchesi; Maria Carmen Collado Journal: Microb Ecol Health Dis Date: 2015-02-02
Authors: Noel T Mueller; Hakdong Shin; Aline Pizoni; Isabel C Werlang; Ursula Matte; Marcelo Z Goldani; Helena A S Goldani; Maria Gloria Dominguez-Bello Journal: Sci Rep Date: 2016-04-01 Impact factor: 4.379
Authors: Derrick M Chu; Kathleen M Antony; Jun Ma; Amanda L Prince; Lori Showalter; Michelle Moller; Kjersti M Aagaard Journal: Genome Med Date: 2016-08-09 Impact factor: 11.117
Authors: R G B O N Freitas; A C J Vasques; G R Fernandes; F B Ribeiro; I Solar; M G Barbosa; B Almeida-Pititto; B Geloneze; S R G Ferreira Journal: Eur J Clin Nutr Date: 2022-07-29 Impact factor: 4.884
Authors: Kamila Gorczyca; Aleksandra Obuchowska; Żaneta Kimber-Trojnar; Magdalena Wierzchowska-Opoka; Bożena Leszczyńska-Gorzelak Journal: Int J Environ Res Public Health Date: 2022-08-12 Impact factor: 4.614
Authors: Marta Selma-Royo; Izaskun García-Mantrana; Marta Calatayud; Anna Parra-Llorca; Cecilia Martínez-Costa; María Carmen Collado Journal: Nutrients Date: 2020-06-15 Impact factor: 5.717
Authors: Silvia Saturio; Alicja M Nogacka; Guadalupe M Alvarado-Jasso; Nuria Salazar; Clara G de Los Reyes-Gavilán; Miguel Gueimonde; Silvia Arboleya Journal: Microorganisms Date: 2021-11-23