Literature DB >> 31596188

Spinal cord infarction in a young adult: What is the culprit?

Maria Khoueiry1, Hussein Moussa1, Raja Sawaya1.   

Abstract

Context: Non-traumatic spinal cord infarction in the young adult is usually associated with a single or multiple genetic mutations. There are certain gene mutations that are more commonly associated with spinal cord infarctions. Homozygous or heterozygous mutations, and single mutations or polymorphism, do not seem to determine the probability of spinal cord infarction.Findings: We add another case of spinal cord infarction in a young adult to the few reported in the literature, and discuss the value of genetic studies and genetic counseling.
Conclusion: Non-traumatic spinal cord infarction is usually caused by a genetic mutation. Early recognition of this entity and definition of the mutation will limit unnecessary and invasive procedures and allows early rehabilitation, preventive measures for complications and genetic counseling.

Entities:  

Keywords:  Gene mutation; Genetic counseling; Hypercoagulable state; Spinal cord infarction; Young adult

Mesh:

Year:  2019        PMID: 31596188      PMCID: PMC8725759          DOI: 10.1080/10790268.2019.1671077

Source DB:  PubMed          Journal:  J Spinal Cord Med        ISSN: 1079-0268            Impact factor:   1.985


  21 in total

1.  Homozygous methylenetetrahydrofolate reductase C677T mutation in a woman with spinal cord infarction.

Authors:  R A R Mahfouz; Z K Otrock; Z M Kanaan; R A Sawaya; A T Taher
Journal:  Eur J Neurol       Date:  2006-09       Impact factor: 6.089

2.  Acute quadriplegia in a young man secondary to prothrombin G20210A mutation.

Authors:  R Sawaya; Z Diken; R Mahfouz
Journal:  Spinal Cord       Date:  2011-03-29       Impact factor: 2.772

3.  [Spinal cord infarction and recurrent venous thrombosis in association with estrogens and the 20210A allele of the prothrombin gene].

Authors:  A J González-Ordóñez; D F Uria; D Ferreiro; M J Barragán; J M Fernández-Carreira; C R Fernández-Alvarez; M G Peliz; M V Alvarez
Journal:  Neurologia       Date:  2001-11       Impact factor: 3.109

4.  Prothrombin G20210A mutation in a child with spinal cord infarction.

Authors:  G Young; K A Krohn; R J Packer
Journal:  J Pediatr       Date:  1999-06       Impact factor: 4.406

5.  Gene mutations and stroke in the young adult.

Authors:  Abdallah A Araji; Helen R Sawaya; Raja A Sawaya
Journal:  J Stroke Cerebrovasc Dis       Date:  2014-09-18       Impact factor: 2.136

6.  Spinal cord infarction in carriers of methylenetetrahydrofolate reductase-polymorphism-like unique risk factor: report of two cases.

Authors:  V Tejero-Fernández; I Fernández-Rodríguez; M D Membrilla-Mesa; M Arroyo-Morales
Journal:  Spinal Cord       Date:  2014-11       Impact factor: 2.772

Review 7.  Childhood idiopathic spinal cord infarction: Description of 7 cases and review of the literature.

Authors:  Claire Bar; Emmanuel Cheuret; Pierre Bessou; Jean-Michel Pedespan
Journal:  Brain Dev       Date:  2017-05-31       Impact factor: 1.961

8.  High prevalence of hyperhomocysteinemia related to folate deficiency and the 677C-->T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa.

Authors:  Emile K Amouzou; Nicodème W Chabi; Charles E Adjalla; Rosa M Rodriguez-Guéant; François Feillet; Christian Villaume; Ambaliou Sanni; Jean-Louis Guéant
Journal:  Am J Clin Nutr       Date:  2004-04       Impact factor: 7.045

9.  Spinal cord infarction: clinical and magnetic resonance imaging findings and short term outcome.

Authors:  C Masson; J P Pruvo; J F Meder; C Cordonnier; E Touzé; V De La Sayette; M Giroud; J L Mas; D Leys
Journal:  J Neurol Neurosurg Psychiatry       Date:  2004-10       Impact factor: 10.154

10.  Cervical spinal cord infarction associated with the use of oral contraceptives for the treatment of acne in a healthy young woman.

Authors:  F C Meng; J T Lee; G S Peng; Y F Sung
Journal:  J Postgrad Med       Date:  2015 Jan-Mar       Impact factor: 1.476

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