Chao Ma1, Haoyu Li2, Xian Li3, Shuwen Lu4, Jianfeng He1. 1. Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Rd. Nanning 530021 Guangxi Zhuang Autonomous Region, PR China. 2. Graduate School, Guangxi University of Chinese Medicine, 179 Mingxiudong Rd. Nanning 530001 Guangxi Zhuang Autonomous Region, PR China. 3. Faculty of Biology, Medicine & Health, University of Manchester, University of Manchester, Oxford Road, Manchester, Manchester, UK. 4. Department of Ophthalmology, the First Affiliated Hospital of Henan University of Chinese Medicine, 19 Renmin road, Zhengzhou, Henan Province, PR China.
Abstract
Aim: This present study aims to investigate the prognostic value of FGD genes for predicting the overall survival in head and neck squamous cell carcinoma (HNSC) patients. Materials & methods: Clinical information and FGD gene expressions of 513 HNSC patients were obtained from The Cancer Genome Atlas dataset. Kaplan-Meier survival, Pearson correlation coefficient analyses and enrichment analyses were performed based on The Cancer Genome Atlas dataset, as well as FGD gene expressions analysis in normal tissues. Results: The survival analyses showed that high levels of FGD2 and FGD3 mRNA expressions, and the combination of high levels of FGD2 and FGD3 mRNAs were associated with the favorable overall survival in HNSC patients (p < 0.01). Oppositely, no significant correlations (p > 0.05) were observed between gender and race and OS. Conclusion: Our findings suggest that the expression levels of FGD2 and FGD3 mRNAs in HNSC are associated with favorable prognosis and may be regarded as potential prognostic biomarkers.
Aim: This present study aims to investigate the prognostic value of FGD genes for predicting the overall survival in head and neck squamous cell carcinoma (HNSC) patients. Materials & methods: Clinical information and FGD gene expressions of 513 HNSC patients were obtained from The Cancer Genome Atlas dataset. Kaplan-Meier survival, Pearson correlation coefficient analyses and enrichment analyses were performed based on The Cancer Genome Atlas dataset, as well as FGD gene expressions analysis in normal tissues. Results: The survival analyses showed that high levels of FGD2 and FGD3 mRNA expressions, and the combination of high levels of FGD2 and FGD3 mRNAs were associated with the favorable overall survival in HNSC patients (p < 0.01). Oppositely, no significant correlations (p > 0.05) were observed between gender and race and OS. Conclusion: Our findings suggest that the expression levels of FGD2 and FGD3 mRNAs in HNSC are associated with favorable prognosis and may be regarded as potential prognostic biomarkers.
Entities:
Keywords:
TCGA; biomarker; diagnosis; head and neck squamous cell carcinoma; mRNA; prognosis