Literature DB >> 31595941

A three-component approach to isoxazolines and isoxazoles under metal-free conditions.

Dahan Wang1, Feng Zhang, Fuhong Xiao, Guo-Jun Deng.   

Abstract

A 1,3-dipolar cycloaddition of 2-methylquinoline, tert-butyl nitrite (TBN) and alkynes or alkenes for the synthesis of biheteroaryls containing both isoxazoline/isoxazole and quinoline motifs has been developed. In this protocol, TBN serves as a convenient N-O source to convert 2-methylquinoline into intermediate nitrile oxides in situ.

Entities:  

Year:  2019        PMID： 31595941     DOI： 10.1039/c9ob01909j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  2 in total

1.  Solvent-free synthesis of 3,5-isoxazoles via 1,3-dipolar cycloaddition of terminal alkynes and hydroxyimidoyl chlorides over Cu/Al2O3 surface under ball-milling conditions.

Authors:  Rafael A Hernandez R; Kelly Burchell-Reyes; Arthur P C A Braga; Jennifer Keough Lopez; Pat Forgione
Journal:  RSC Adv       Date:  2022-02-23       Impact factor: 3.361

Review 2.  Recent synthetic efforts in the preparation of 2-(3,4)-alkenyl (aryl) quinoline molecules towards anti-kinetoplastid agents.

Authors:  Dayana Orozco; Vladimir V Kouznetsov; Armando Bermúdez; Leonor Y Vargas Méndez; Arturo René Mendoza Salgado; Carlos Mario Meléndez Gómez
Journal:  RSC Adv       Date:  2020-01-29       Impact factor: 4.036
  2 in total

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