Literature DB >> 31595728

Alternative role of noncoding RNAs: coding and noncoding properties.

Gui-Zhen Zheng1, Wei Li2, Zhi-Yong Liu3,4.   

Abstract

Noncoding RNAs (ncRNAs) have played a critical role in cellular biological functions. Recently, some peptides or proteins originating from annotated ncRNAs were identified in organism development and various diseases. Here, we briefly review several novel peptides translated by annotated ncRNAs and related key functions. In addition, we summarize the potential mechanism of bifunctional ncRNAs and propose a specific "switch" triggering the transformation from the noncoding to the coding state under certain stimuli or cellular stress. The coding properties of ncRNAs and their peptide products may provide a novel horizon in proteomic research and can be regarded as a potential therapeutic target for the treatment of various diseases.

Keywords:  Non-coding RNA; Biological function; Micropeptides; Cellular stress

Mesh：

Substances：

Year:  2019        PMID： 31595728      PMCID： PMC6825815          DOI： 10.1631/jzus.B1900336

Source DB:  PubMed          Journal:  J Zhejiang Univ Sci B        ISSN： 1673-1581            Impact factor:   3.066


  56 in total

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Review 3.  Noncoding RNAs in Growth and Death of Cancer Cells.

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4.  PANCR, the PITX2 Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression.

Authors:  Shamone R Gore-Panter; Jeffrey Hsu; John Barnard; Christine S Moravec; David R Van Wagoner; Mina K Chung; Jonathan D Smith
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Authors:  Pengpeng Bi; Andres Ramirez-Martinez; Hui Li; Jessica Cannavino; John R McAnally; John M Shelton; Efrain Sánchez-Ortiz; Rhonda Bassel-Duby; Eric N Olson
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Authors:  Zhigui Li; Shuang Hao; Hongqiang Yin; Jing Gao; Zhuo Yang
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Authors:  Jin-Zhou Huang; Min Chen; Xing-Cheng Gao; Song Zhu; Hongyang Huang; Min Hu; Huifang Zhu; Guang-Rong Yan
Journal:  Mol Cell       Date:  2017-10-05       Impact factor: 17.970

9.  DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation.

Authors:  Noa Liberman; Valentina Gandin; Yuri V Svitkin; Maya David; Geneviève Virgili; Maritza Jaramillo; Martin Holcik; Bhushan Nagar; Adi Kimchi; Nahum Sonenberg
Journal:  Nucleic Acids Res       Date:  2015-03-16       Impact factor: 16.971

Review 10.  Cytoplasmic viral replication complexes.

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Journal:  Cell Host Microbe       Date:  2010-07-22       Impact factor: 21.023
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  1 in total

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  1 in total

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