Signe Taasti Andersen1, Susanne Elisabeth Pors1, Liv la Cour Poulsen2, Lotte Berdiin Colmorn3, Kirsten Tryde Macklon3, Erik Ernst4, Peter Humaidan5, Claus Yding Andersen1, Stine Gry Kristensen6. 1. Laboratory of Reproductive Biology, Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark. 2. The Fertility Clinic, Department of Gynecology and Obstetrics, Zealand University Hospital, Køge, Denmark. 3. The Fertility Clinic, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark. 4. The Fertility Clinic, Horsens Regional Hospital, Horsens, Denmark. 5. The Fertility Clinic, Skive Regional Hospital and Faculty of Health, Aarhus University, Skive, Denmark. 6. Laboratory of Reproductive Biology, Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark. Electronic address: stine.gry.kristensen@regionh.dk.
Abstract
OBJECTIVE: To systematically review reproductive outcomes of assisted reproductive technology (ART) treatment in women transplanted with frozen-thawed ovarian tissue. DESIGN: Systematic review in accordance with guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). SETTING: Not applicable. PATIENT(S): Women undergoing ovarian tissue transplantation (OTT) and subsequent ART. INTERVENTION(S): Literature search in PubMed and Scopus databases. MAIN OUTCOME MEASURE(S): Time from OTT to initiation of ART, stimulation protocol, and conventional ART outcome measures. RESULT(S): Twenty studies (including 15 case reports), specifying ART treatments and outcomes of 40 women undergoing OTT were identified. Multiple stimulation protocols were applied, with the modified natural cycle as the most frequently used. In total, 195 ART cycles were performed (4.0 cycles per patient) resulting in 1.5 follicles and 1.0 mature oocyte retrieved per cycle. Empty follicle rates ranged from 23% to 35% in the three largest cohort studies. Twenty-five women (62.5%) had one or more pregnancies, of which 28.6% were lost, resulting in a total of 20 live births (22 children). Overall the pregnancy rates varied from 3.9% to 19.3% and live-birth rates from 3.9% to 14.0% per cycle in the three cohort studies. Fertility treatment was initiated shortly after OTT in some centers, while others awaited natural conception before embarking on ART treatment. CONCLUSION(S): The reported pregnancy and live-birth rates for women undergoing OTT and ART were considerably lower than those of the general in vitro fertilization (IVF) population, corresponding to patients with poor ovarian reserve. In general, ART outcomes are underreported, and there is a lack of consensus regarding the timing of ART in relation to OTT and the type of ovarian stimulation protocol.
OBJECTIVE: To systematically review reproductive outcomes of assisted reproductive technology (ART) treatment in women transplanted with frozen-thawed ovarian tissue. DESIGN: Systematic review in accordance with guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). SETTING: Not applicable. PATIENT(S): Women undergoing ovarian tissue transplantation (OTT) and subsequent ART. INTERVENTION(S): Literature search in PubMed and Scopus databases. MAIN OUTCOME MEASURE(S): Time from OTT to initiation of ART, stimulation protocol, and conventional ART outcome measures. RESULT(S): Twenty studies (including 15 case reports), specifying ART treatments and outcomes of 40 women undergoing OTT were identified. Multiple stimulation protocols were applied, with the modified natural cycle as the most frequently used. In total, 195 ART cycles were performed (4.0 cycles per patient) resulting in 1.5 follicles and 1.0 mature oocyte retrieved per cycle. Empty follicle rates ranged from 23% to 35% in the three largest cohort studies. Twenty-five women (62.5%) had one or more pregnancies, of which 28.6% were lost, resulting in a total of 20 live births (22 children). Overall the pregnancy rates varied from 3.9% to 19.3% and live-birth rates from 3.9% to 14.0% per cycle in the three cohort studies. Fertility treatment was initiated shortly after OTT in some centers, while others awaited natural conception before embarking on ART treatment. CONCLUSION(S): The reported pregnancy and live-birth rates for women undergoing OTT and ART were considerably lower than those of the general in vitro fertilization (IVF) population, corresponding to patients with poor ovarian reserve. In general, ART outcomes are underreported, and there is a lack of consensus regarding the timing of ART in relation to OTT and the type of ovarian stimulation protocol.
Authors: Fatemeh Anbari; Mohammad Ali Khalili; Maryam Mahaldashtian; Alireza Ahmadi; Maria Grazia Palmerini Journal: Turk J Obstet Gynecol Date: 2022-06-27
Authors: Esther H Chung; Stephanie L Lim; Evan Myers; Haley A Moss; Kelly S Acharya Journal: J Assist Reprod Genet Date: 2021-05-11 Impact factor: 3.357
Authors: M Vatel; A Torre; B Paillusson; F Scheffler; M Bergere; M Benkhalifa; M-T Le Martelot; F Leperlier; S Mirallié; L Selleret; M Prades-Borio; A Neuraz; V Barraud-Lange; N Boissel; A Fortin; C Poirot Journal: J Assist Reprod Genet Date: 2021-01-03 Impact factor: 3.412