A comparison of the effect of paroxetine and amitriptyline on the tyramine pressor response test.

The effect of single and repeated dosing of paroxetine on the in vivo noradrenaline uptake process, as determined by tyramine pressor response tests, was evaluated in normal healthy subjects. No statistically significant inhibition of the uptake process was observed for paroxetine, nor did it produce sedation or dryness of the mouth, though effects were observed for amitriptyline.