Priyanka Sharma1, Tushar Joshi2, Tanuja Joshi3, Subhash Chandra4, Sushma Tamta5. 1. Department of Botany, D.S.B. Campus, Kumaun University, Nainital, 263002, Uttarakhand, India. Electronic address: priyancisharma@gmail.com. 2. Department of Biotechnology, Bhimtal Campus, Kumaun University, Nainital, 263136, Uttarakhand, India. Electronic address: tjoshi6869@gmail.com. 3. Department of Botany, S.S.J Campus, Almora, Kumaun University, Nainital, 263601, Uttarakhand, India. Electronic address: joshitanuja222@gmail.com. 4. Department of Botany, S.S.J Campus, Almora, Kumaun University, Nainital, 263601, Uttarakhand, India. Electronic address: scjnu@yahoo.co.in. 5. Department of Botany, D.S.B. Campus, Kumaun University, Nainital, 263002, Uttarakhand, India. Electronic address: sushmatamta@gmail.com.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Phyllanthus emblica Linn. (Syn. Emblica officinalis Gaertn.), has been used to cure many ailments of human beings. Literature survey demonstrates that it has many pharmacological activities i.e. antidiabetic, antioxidant, anti-microbial, antifungal, antiallergic, antiviral, and anticancer properties. AIM OF THE STUDY: The present study aimed to identify the novel plant-derived antidiabetic compounds from P. emblica to understand the molecular basis of antidiabetic activities. MATERIAL AND METHODS: Text mining analysis of P. emblica and its disease association was carried out using server DLAD4U. Due to the highest score of P. emblica with diabetes, the virtual screening of a phytochemical library of P. emblica against three targets of diabetes was carried out. After that FAF-Drug4, admetSAR and DruLiTo servers were used for drug-likeness prediction. Additionally, pharmacophore modeling was also carried out to understand the antidiabetic activity of screened compounds. RESULTS: The docking scores, drug-likeness and pharmacophore studies found that Ellagic acid, Estradiol, Sesamine, Kaempferol, Zeatin, Quercetin, and Leucodelphinidin are potential antidiabetic compounds. CONCLUSIONS: Our study shows that phytochemicals of P. emblica are very potential antidiabetic candidates. Using the modern techniques these molecules could be used to develop an effective antidiabetic drugs from a natural resource.
ETHNOPHARMACOLOGICAL RELEVANCE: Phyllanthus emblica Linn. (Syn. Emblica officinalis Gaertn.), has been used to cure many ailments of human beings. Literature survey demonstrates that it has many pharmacological activities i.e. antidiabetic, antioxidant, anti-microbial, antifungal, antiallergic, antiviral, and anticancer properties. AIM OF THE STUDY: The present study aimed to identify the novel plant-derived antidiabetic compounds from P. emblica to understand the molecular basis of antidiabetic activities. MATERIAL AND METHODS: Text mining analysis of P. emblica and its disease association was carried out using server DLAD4U. Due to the highest score of P. emblica with diabetes, the virtual screening of a phytochemical library of P. emblica against three targets of diabetes was carried out. After that FAF-Drug4, admetSAR and DruLiTo servers were used for drug-likeness prediction. Additionally, pharmacophore modeling was also carried out to understand the antidiabetic activity of screened compounds. RESULTS: The docking scores, drug-likeness and pharmacophore studies found that Ellagic acid, Estradiol, Sesamine, Kaempferol, Zeatin, Quercetin, and Leucodelphinidin are potential antidiabetic compounds. CONCLUSIONS: Our study shows that phytochemicals of P. emblica are very potential antidiabetic candidates. Using the modern techniques these molecules could be used to develop an effective antidiabetic drugs from a natural resource.