Marco A Perrone1,2,3, Paola Gualtieri4, Santo Gratteri5, Wahid Ali6, Domenico Sergi1, Saverio Muscoli1, Andrea Cammarano4, Sergio Bernardini2,3, Laura Di Renzo4, Francesco Romeo1. 1. Division of Cardiology. 2. Division of Clinical Biochemistry and Clinical Molecular Biology. 3. University Sports Centre. 4. Division of Clinical Nutrition and Nutrigenomics, University of Rome Tor Vergata, Rome. 5. Department of Surgery and Medical Science, Magna Græcia University, Catanzaro, Germaneto, Italy. 6. Department of Pathology, King George S. Medical University, Lucknow, Uttar Pradesh, India.
Abstract
BACKGROUND AND AIM: Cardiovascular diseases (CVDs) are the most frequent causes of death in the world. Inflammation and oxidative damage contribute significantly to the development of atherosclerosis and CVDs. European Food Safety Authority scientific opinion has acknowledged that hydroxytyrosol (3,4-dihydroxyphenylethanol) and derivatives, contained in extra virgin olive oil (EVOO), typically used in Mediterranean diet may play a crucial role in the reduction of the inflammatory pathway and in the prevention of CVDs. The aim of the study was to determine the effect in healthy volunteers of 25 g of phenols-rich EVOO (p-EVOO). METHODS: The clinical study was a randomized, controlled trial to determine the acute effect in the postprandial time of 25 g of p-EVOO. We evaluated nutritional status using anthropometric parameters, body composition, serum metabolites, oxidative stress biomarkers and gene expression of eight genes related to oxidative stress and human inflammasome pathways, lasting 2 h after p-EVOO administration. Twenty-two participants resulted as eligible for the study. RESULTS: A significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index was highlighted (P < 0.05). Significant upregulation of catalase, superoxide dismutase 1 and upstream transcription factor 1 were observed (P < 0.05). CONCLUSION: The current study shows that intake of 25 g of p-EVOO has been able to be modulated, in the postprandial time, the antioxidant profile and the expression of inflammation and oxidative stress-related genes, as superoxide dismutase 1, upstream transcription factor 1 and catalase. We also observed a significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index. We have demonstrated that a daily intake of phenols and antioxidants can reduce the inflammatory pathway and oxidative stress and therefore the risk of atherosclerosis and CVDs. More studies on a larger population are necessary before definitive conclusions can be drawn.Trial registration ClinicalTrials.gov NCT01890070.
RCT Entities:
BACKGROUND AND AIM: Cardiovascular diseases (CVDs) are the most frequent causes of death in the world. Inflammation and oxidative damage contribute significantly to the development of atherosclerosis and CVDs. European Food Safety Authority scientific opinion has acknowledged that hydroxytyrosol (3,4-dihydroxyphenylethanol) and derivatives, contained in extra virgin olive oil (EVOO), typically used in Mediterranean diet may play a crucial role in the reduction of the inflammatory pathway and in the prevention of CVDs. The aim of the study was to determine the effect in healthy volunteers of 25 g of phenols-rich EVOO (p-EVOO). METHODS: The clinical study was a randomized, controlled trial to determine the acute effect in the postprandial time of 25 g of p-EVOO. We evaluated nutritional status using anthropometric parameters, body composition, serum metabolites, oxidative stress biomarkers and gene expression of eight genes related to oxidative stress and human inflammasome pathways, lasting 2 h after p-EVOO administration. Twenty-two participants resulted as eligible for the study. RESULTS: A significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index was highlighted (P < 0.05). Significant upregulation of catalase, superoxide dismutase 1 and upstream transcription factor 1 were observed (P < 0.05). CONCLUSION: The current study shows that intake of 25 g of p-EVOO has been able to be modulated, in the postprandial time, the antioxidant profile and the expression of inflammation and oxidative stress-related genes, as superoxide dismutase 1, upstream transcription factor 1 and catalase. We also observed a significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index. We have demonstrated that a daily intake of phenols and antioxidants can reduce the inflammatory pathway and oxidative stress and therefore the risk of atherosclerosis and CVDs. More studies on a larger population are necessary before definitive conclusions can be drawn.Trial registration ClinicalTrials.gov NCT01890070.
Authors: Desirée Victoria-Montesinos; Raúl Arcusa; Ana María García-Muñoz; Silvia Pérez-Piñero; Maravillas Sánchez-Macarro; Antonio Avellaneda; Francisco Javier López-Román Journal: Nutrients Date: 2021-04-27 Impact factor: 5.717
Authors: Cielo García-Montero; Oscar Fraile-Martínez; Ana M Gómez-Lahoz; Leonel Pekarek; Alejandro J Castellanos; Fernando Noguerales-Fraguas; Santiago Coca; Luis G Guijarro; Natalio García-Honduvilla; Angel Asúnsolo; Lara Sanchez-Trujillo; Guillermo Lahera; Julia Bujan; Jorge Monserrat; Melchor Álvarez-Mon; Miguel A Álvarez-Mon; Miguel A Ortega Journal: Nutrients Date: 2021-02-22 Impact factor: 5.717