Rita Rb-Silva1,2,3, Ana Goios1,2, Christine Kelly4, Pedro Teixeira1,2, Cristina João5,6, Ana Horta1,2,7, Margarida Correia-Neves1,2,8. 1. Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal. 2. ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal. 3. Department of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal. 4. HIV Molecular Research Group, University College Dublin, Dublin, Ireland. 5. NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal. 6. Champalimaud Centre for the Unknown, Fundação Champalimaud, Lisboa, Portugal. 7. Department of Infectious Diseases, Centro Hospitalar do Porto, Porto, Portugal. 8. Division of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Abstract
BACKGROUND: Terms and criteria to classify people living with HIV on antiretroviral therapy who fail to achieve satisfactory CD4 T-cell counts are heterogeneous, and need revision and summarization. METHODS: We performed a systematic review of PubMed original research articles containing a set of predefined terms, published in English between January 2009 and September 2018. The search retrieved initially 1360 studies, of which 103 were eligible. The representative terminology and criteria were extracted and analyzed. RESULTS: Twenty-two terms and 73 criteria to define the condition were identified. The most frequent term was "immunological nonresponders" and the most frequent criterion was "CD4 T-cell count <350 cells/µL after ≥24 months of virologic suppression." Most criteria use CD4+ T-cell counts as a surrogate, either as an absolute value or as a change after a defined period of time [corrected]. Distinct values and time points were used. Only 9 of the 73 criteria were used by more than one independent research team. Herein we propose 2 criteria that could help to reach a consensus. CONCLUSIONS: The high disparity in terms and criteria here reported precludes data aggregation and progression of the knowledge on this condition, because it renders impossible to compare data from different studies. This review will foster the discussion of terms and criteria to achieve a consensual definition.
BACKGROUND: Terms and criteria to classify people living with HIV on antiretroviral therapy who fail to achieve satisfactory CD4 T-cell counts are heterogeneous, and need revision and summarization. METHODS: We performed a systematic review of PubMed original research articles containing a set of predefined terms, published in English between January 2009 and September 2018. The search retrieved initially 1360 studies, of which 103 were eligible. The representative terminology and criteria were extracted and analyzed. RESULTS: Twenty-two terms and 73 criteria to define the condition were identified. The most frequent term was "immunological nonresponders" and the most frequent criterion was "CD4 T-cell count <350 cells/µL after ≥24 months of virologic suppression." Most criteria use CD4+ T-cell counts as a surrogate, either as an absolute value or as a change after a defined period of time [corrected]. Distinct values and time points were used. Only 9 of the 73 criteria were used by more than one independent research team. Herein we propose 2 criteria that could help to reach a consensus. CONCLUSIONS: The high disparity in terms and criteria here reported precludes data aggregation and progression of the knowledge on this condition, because it renders impossible to compare data from different studies. This review will foster the discussion of terms and criteria to achieve a consensual definition.
Authors: Eric G Meissner; Dongjun Chung; Betty Tsao; David W Haas; Netanya S Utay Journal: AIDS Res Hum Retroviruses Date: 2020-11-11 Impact factor: 1.723
Authors: Marta Sisteré-Oró; Naina Andrade; Diana D J Wortmann; Juan Du; Natalia Garcia-Giralt; María González-Cao; Robert Güerri-Fernández; Andreas Meyerhans Journal: Front Immunol Date: 2022-08-26 Impact factor: 8.786