Crystian B Oliveira1, Chris G Maher2,3, Marcia R Franco4, Steven J Kamper2,3,5, Christopher M Williams5,6,7, Fernanda G Silva1, Rafael Z Pinto2,8. 1. Department of Physical Therapy, Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista (UNESP), Presidente Prudente, Brazil. 2. Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. 3. Institute for Musculoskeletal Health, Sydney, Australia. 4. Department of Physical Therapy, Centro Universitário UNA, Contagem, Brazil. 5. Centre for Pain, Health and Lifestyle, New Lambton Heights, Australia. 6. Hunter New England Population Health, Hunter New England Local Health District, New Lambton, NSW, Australia. 7. School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia. 8. Department of Physical Therapy, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Abstract
OBJECTIVE: To determine the magnitude of the association between cardiovascular disease and chronic musculoskeletal pain. DESIGN: Systematic review with meta-analysis. METHODS: A comprehensive search was performed in five electronic databases. Population-based studies reporting the prevalence of cardiovascular diseases in adults stratified by chronic musculoskeletal pain status were considered eligible. Two independent reviewers performed the screening of the records following the inclusion criteria, extracted data, and evaluated the risk of bias of the included studies using an assessment tool of risk of bias for observational studies. In addition, we assessed the overall quality of evidence using an adaptation of the GRADE approach for prognosis. RESULTS: Twenty studies were included in this review. There was high-quality evidence that people with chronic musculoskeletal pain are 1.91 times more likely to report having a cardiovascular disease compared with those without chronic musculoskeletal pain (risk ratio = 1.91, 95% confidence interval = 1.64-2.21). CONCLUSIONS: Our findings demonstrated associations between chronic musculoskeletal pain and any cardiovascular diseases. Future studies are still warranted to better understand the association between chronic musculoskeletal pain and the specific types of cardiovascular diseases.
OBJECTIVE: To determine the magnitude of the association between cardiovascular disease and chronic musculoskeletal pain. DESIGN: Systematic review with meta-analysis. METHODS: A comprehensive search was performed in five electronic databases. Population-based studies reporting the prevalence of cardiovascular diseases in adults stratified by chronic musculoskeletal pain status were considered eligible. Two independent reviewers performed the screening of the records following the inclusion criteria, extracted data, and evaluated the risk of bias of the included studies using an assessment tool of risk of bias for observational studies. In addition, we assessed the overall quality of evidence using an adaptation of the GRADE approach for prognosis. RESULTS: Twenty studies were included in this review. There was high-quality evidence that people with chronic musculoskeletal pain are 1.91 times more likely to report having a cardiovascular disease compared with those without chronic musculoskeletal pain (risk ratio = 1.91, 95% confidence interval = 1.64-2.21). CONCLUSIONS: Our findings demonstrated associations between chronic musculoskeletal pain and any cardiovascular diseases. Future studies are still warranted to better understand the association between chronic musculoskeletal pain and the specific types of cardiovascular diseases.
Authors: Eric J Roseen; Iniya Rajendran; Peter Stein; Lisa Fredman; Howard A Fink; Michael P LaValley; Robert B Saper Journal: J Gen Intern Med Date: 2021-04-19 Impact factor: 6.473
Authors: Zachary L Mannes; Malki Stohl; David S Fink; Mark Olfson; Katherine M Keyes; Silvia S Martins; Jaimie L Gradus; Andrew J Saxon; Charles Maynard; Ofir Livne; Sarah Gutkind; Deborah S Hasin Journal: J Gen Intern Med Date: 2022-01-19 Impact factor: 6.473