| Literature DB >> 3159136 |
U Godden, J Herbert, R D Stewart, B Roser.
Abstract
During treatment of heart-grafted rats with cyclosporine, an unusual large lymphocyte appears in the blood. These cells constitute up to 40% of the peripheral blood leukocyte population and carry both the T helper/DTH and T cytotoxic/suppressor differentiation antigens. They require both the allograft and CsA for their generation and are not recently thymus-derived. They gradually disappear after stopping CsA treatment, although the treated rats remain tolerant of the graft.Entities:
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Year: 1985 PMID： 3159136 DOI： 10.1097/00007890-198506000-00010
Source DB: PubMed Journal: Transplantation ISSN： 0041-1337 Impact factor: 4.939