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Literature DB >> 315910

Human pancreatic amylase polymorphism: formal genetics and population genetics.

Abstract

The genetically determined polymorphism of human pancreatic amylase (E.C. 3.2.1.1), AMY2, is demonstrated in serum specimens by agarose gel electrophoresis. We investigated 325 mother-child pairs and 2594 unrelated individuals from southwestern Germany. This study confirms the formal hypothesis of two common alleles AMY1/2, AMY2/2 and possibly two rare alleles AMY3/2, AMY4/2 at an autosomal locus AMY2. The frequency of the AMY1/2 allele was calculated as 0.951; AMY3/2 and AMY4/2 seem to have a frequency of 0.001 in this sample.

Entities: Chemical Disease Gene Species

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Year: 1979 PMID： 315910 DOI： 10.1007/bf00287179

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

5 in total

4 in total

Human pancreatic amylase polymorphism: formal genetics and population genetics.

1. Human amylase loci: genetic linkage with the Duffy blood group locus and assignment to linkage group I.

2. Salivary and pancreatic amylase: electrophoretic characterizations and genetic studies.

3. Possible linkage between uncoiler chromosome Un 1 and amylase polymorphism Amy 2 loci.

4. Amylase heterogeneity. Some genetik and clinical aspects.

5. Amylase heterogeneity in man.

1. Ultrathin-layer isoelectrofocusing for rapid diagnosis of protein variants.

2. Gene frequencies of pancreatic amylase (Amy2) in Western Germany (Düsseldorf region).

3. [Macroamylasemia. Immunoglobulin a-amylase-complexes as rare cause of hyperamylasemia (author's transl)].

4. Serum amylase activity altered by the ABO blood group system in Chinese subjects.