Hassan Tavassoli1, Ali Heidarianpour1, Mehdi Hedayati2. 1. Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Bu-Ali Sina University, Hamedan, Iran. 2. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: We investigated the effects of high-fat diet (HFD) consumption combined with diabetes induction, resistance exercise training (RET) and a de-training period on circulating irisin levels and selective metabolic parameters. MATERIAL AND METHODS: Rats were assigned to four groups (n = 8): healthy non-diabetic rats (NDC), non-diabetic rats that performed RET (NDR), sedentary HFD-fed/STZ-treated rats (HFD/STZ) and HFD-fed/STZ-treated rats that performed RET (HFD/STZ + RE). RESULTS: HFD consumption reduced irisin level and Quicki (p < .01). After the 12-week period, levels of TC, TG, HOMA1-IR, HOMA2-IR and irisin were also lower in the HFD/STZ + RE group compared to the HFD/STZ group. Body weight and HOMA1-IR showed a positive (r = 0.558 and r = 0.538) whereas TC and LDL-C had a negative correlation (r = -0.461 and r = -0.630) with irisin level (p < .05). CONCLUSIONS: Irisin level increased along with the progress of obesity and T2DM. It seems that RET can attenuate the increase of irisin in those conditions by improvement of glucose/lipid metabolic disorders.
BACKGROUND: We investigated the effects of high-fat diet (HFD) consumption combined with diabetes induction, resistance exercise training (RET) and a de-training period on circulating irisin levels and selective metabolic parameters. MATERIAL AND METHODS: Rats were assigned to four groups (n = 8): healthy non-diabetic rats (NDC), non-diabetic rats that performed RET (NDR), sedentary HFD-fed/STZ-treated rats (HFD/STZ) and HFD-fed/STZ-treated rats that performed RET (HFD/STZ + RE). RESULTS: HFD consumption reduced irisin level and Quicki (p < .01). After the 12-week period, levels of TC, TG, HOMA1-IR, HOMA2-IR and irisin were also lower in the HFD/STZ + RE group compared to the HFD/STZ group. Body weight and HOMA1-IR showed a positive (r = 0.558 and r = 0.538) whereas TC and LDL-C had a negative correlation (r = -0.461 and r = -0.630) with irisin level (p < .05). CONCLUSIONS: Irisin level increased along with the progress of obesity and T2DM. It seems that RET can attenuate the increase of irisin in those conditions by improvement of glucose/lipid metabolic disorders.
Entities:
Keywords:
Irisin; Obesity; de-training; resistance exercise training; type 2 diabetes
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