Jakub Kornacki1, Przemysław Wirstlein2, Ewa Wender-Ozegowska2. 1. Division of Reproduction, Department of Obstetrics, Gynecology, and Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: kuba.kornacki@wp.pl. 2. Division of Reproduction, Department of Obstetrics, Gynecology, and Gynecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland.
Abstract
OBJECTIVE: The study aimed to assess serum levels of syndecan-1 (SDC-1) and hyaluronan (HA) in patients with early- and late-onset preeclampsia (PE). STUDY DESIGN: Blood samples were collected in the third trimester of pregnancy from 20 women with early-onset PE, 20 with late-onset PE, and 20 with normal pregnancy for the assessment of serum levels of SDC-1 and HA as markers of endothelial injury. PE was categorized as early-onset when diagnosed at <34 weeks of gestation and as late-onset when diagnosed at ≥34 weeks of gestation. MAIN OUTCOME MEASURES: The degree of endothelial injury in different forms of preeclampsia expressed by serum concentrations of SDC-1 and HA. RESULTS: Concentration of HA was significantly higher and the level of SDC-1 was significantly lower in patients with PE than in the control group. However, the concentrations of both HA and SDC-1 did not differ significantly between the two groups of PE. CONCLUSIONS: Degree of endothelium injury is comparable in patients with early- and late-onset PE.
OBJECTIVE: The study aimed to assess serum levels of syndecan-1 (SDC-1) and hyaluronan (HA) in patients with early- and late-onset preeclampsia (PE). STUDY DESIGN: Blood samples were collected in the third trimester of pregnancy from 20 women with early-onset PE, 20 with late-onset PE, and 20 with normal pregnancy for the assessment of serum levels of SDC-1 and HA as markers of endothelial injury. PE was categorized as early-onset when diagnosed at <34 weeks of gestation and as late-onset when diagnosed at ≥34 weeks of gestation. MAIN OUTCOME MEASURES: The degree of endothelial injury in different forms of preeclampsia expressed by serum concentrations of SDC-1 and HA. RESULTS: Concentration of HA was significantly higher and the level of SDC-1 was significantly lower in patients with PE than in the control group. However, the concentrations of both HA and SDC-1 did not differ significantly between the two groups of PE. CONCLUSIONS: Degree of endothelium injury is comparable in patients with early- and late-onset PE.
Authors: Marina M Ziganshina; Ekaterina L Yarotskaya; Nicolai V Bovin; Stanislav V Pavlovich; Gennady T Sukhikh Journal: Int J Mol Sci Date: 2020-04-26 Impact factor: 5.923
Authors: Ayşe Anık; Özge Çevik; Sercan Öztürk; Ayça Tuzcu; Abdullah Barış Akcan; Emre Zafer; Münevver Kaynak Türkmen; Ahmet Anık Journal: Turk Arch Pediatr Date: 2022-01