Literature DB >> 3158631

Spectinomycin modification. III. Spectinomycin analogs with C-3'-branched chain sugars.

R C Thomas, E L Fritzen.   

Abstract

A variety of C-3'-branched chain analogs of spectinomycin has been synthesized via the intermediacy of spectinomycin derived diazoketones. In vitro antibacterial assay of these compounds has underscored the importance of hydrogen bonding functional groups in this region of the molecule. The most potent of these analogs had activity greater than or equal to the parent.

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Year:  1985        PMID： 3158631     DOI： 10.7164/antibiotics.38.208

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.

Authors:  Jiuyu Liu; David F Bruhn; Robin B Lee; Zhong Zheng; Tanja Janusic; Dimitri Scherbakov; Michael S Scherman; Helena I Boshoff; Sourav Das; Samanthi L Waidyarachchi; Tiffany A Brewer; Begoña Gracia; Lei Yang; John Bollinger; Gregory T Robertson; Bernd Meibohm; Anne J Lenaerts; Jose Ainsa; Erik C Böttger; Richard E Lee
Journal:  ACS Infect Dis       Date:  2016-11-11       Impact factor: 5.084

2.  Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.

Authors:  David F Bruhn; Samanthi L Waidyarachchi; Dora B Madhura; Dimitri Shcherbakov; Zhong Zheng; Jiuyu Liu; Yasser M Abdelrahman; Aman P Singh; Stefan Duscha; Chetan Rathi; Robin B Lee; Robert J Belland; Bernd Meibohm; Jason W Rosch; Erik C Böttger; Richard E Lee
Journal:  Sci Transl Med       Date:  2015-05-20       Impact factor: 17.956

3.  In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog.

Authors:  G E Zurenko; B H Yagi; J J Vavra; B B Wentworth
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191

4.  Human safety and pharmacokinetics of a single intramuscular dose of a novel spectinomycin analog, trospectomycin (U-63,366F).

Authors:  E Novak; L M Paxton; A Bye; R Patel; G E Zurenko; S F Francom
Journal:  Antimicrob Agents Chemother       Date:  1990-12       Impact factor: 5.191

5.  Antibacterial activity of trospectomycin (U-63366F) and initial evaluations of disk diffusion susceptibility tests.

Authors:  A L Barry; R N Jones; C Thornsberry
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

6.  Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Authors:  Richard E Lee; Julian G Hurdle; Jiuyu Liu; David F Bruhn; Tanja Matt; Michael S Scherman; Bernd Meibohm; Erik C Böttger; Anne J Lenaerts; Pavan K Vaddady; Zhong Zheng; Jianjun Qi; Rashid Akbergenov; Sourav Das; Dora B Madhura; Chetan Rathi; Ashit Trivedi; Cristina Villellas; Robin B Lee; Samanthi L Waidyarachchi; Dianqing Sun; Michael R McNeil; Jose A Ainsa; Helena I Boshoff; Mercedes Gonzalez-Juarrero
Journal:  Nat Med       Date:  2014-01-26       Impact factor: 53.440
  6 in total

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