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Literature DB >> 31585876

AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals.

Laura Sala¹, Srividya Chandrasekhar¹, Joana A Vidigal².

Abstract

Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex that promotes both decay and translational repression; the siRNA pathway represses transcripts through direct Ago2-mediated cleavage. Here, we review our current knowledge of mechanistic details and physiological requirements of both these pathways and briefly discuss their implications to human disease.

Entities: Chemical

Mesh：

Substances：

Year: 2020 PMID： 31585876 PMCID： PMC6827344 DOI： 10.2741/4793

Source DB: PubMed Journal: Front Biosci (Landmark Ed) ISSN： 2768-6698

270 in total

1. Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.

Authors: Yuichiro Mishima; Akira Fukao; Tomoyoshi Kishimoto; Hiroshi Sakamoto; Toshinobu Fujiwara; Kunio Inoue
Journal: Proc Natl Acad Sci U S A Date: 2012-01-09 Impact factor: 11.205

2. Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation.

Authors: Yijun Qi; Xingyue He; Xiu-Jie Wang; Oleksiy Kohany; Jerzy Jurka; Gregory J Hannon
Journal: Nature Date: 2006-09-24 Impact factor: 49.962

3. Accurate Chromosome Segregation at First Meiotic Division Requires AGO4, a Protein Involved in RNA-Dependent DNA Methylation in Arabidopsis thaliana.

Authors: Cecilia Oliver; Juan Luis Santos; Mónica Pradillo
Journal: Genetics Date: 2016-07-27 Impact factor: 4.562

4. Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas.

Authors: Dionysios J Papachristou; Angeliki Korpetinou; Efstathia Giannopoulou; Anna G Antonacopoulou; Helen Papadaki; Petros Grivas; Chrisoula D Scopa; Haralabos P Kalofonos
Journal: Virchows Arch Date: 2011-07-18 Impact factor: 4.064

5. Adaptive regulation of testis gene expression and control of male fertility by the Drosophila hairpin RNA pathway. [Corrected].

Authors: Jiayu Wen; Hong Duan; Fernando Bejarano; Katsutomo Okamura; Lacramioara Fabian; Julie A Brill; Diane Bortolamiol-Becet; Raquel Martin; J Graham Ruby; Eric C Lai
Journal: Mol Cell Date: 2014-12-24 Impact factor: 17.970

AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals.

1. Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.

2. Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation.

3. Accurate Chromosome Segregation at First Meiotic Division Requires AGO4, a Protein Involved in RNA-Dependent DNA Methylation in Arabidopsis thaliana.

4. Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas.

5. Adaptive regulation of testis gene expression and control of male fertility by the Drosophila hairpin RNA pathway. [Corrected].

6. R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway.

7. Argonaute 2 is up-regulated in tissues of urothelial carcinoma of bladder.

8. Distance constraints between microRNA target sites dictate efficacy and cooperativity.

9. Ago1 Interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells.

10. MiRNA-99a directly regulates AGO2 through translational repression in hepatocellular carcinoma.

Review 1. Roles of the Core Components of the Mammalian miRISC in Chromatin Biology.