Jose Stalin Bayas Escudero1, Maria Gabriela Benitez Perez1, Marcelie Priscila de Oliveira Rosso1, Daniela Vieira Buchaim2, Karina Torres Pomini1, Leila Maria Guissoni Campos3, Mauro Audi4, Rogério Leone Buchaim5. 1. Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru, SP, Brazil. 2. Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru, SP, Brazil; Medical School, Discipline of Human Morphophysiology, University of Marilia (UNIMAR), Marília, SP, Brazil; Medical School, Discipline of Neuroanatomy, University Center of Adamantina (UNIFAI), Adamantina, SP, Brazil. 3. Medical School, Discipline of Human Morphophysiology, University of Marilia (UNIMAR), Marília, SP, Brazil. 4. Physiotherapy School, University of Marilia (UNIMAR), Marília-SP, Brazil. 5. Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru, SP, Brazil; Medical School, Discipline of Human Morphophysiology, University of Marilia (UNIMAR), Marília, SP, Brazil. Electronic address: rogerio@fob.usp.br.
Abstract
BACKGROUND: Photobiomodulation therapy (PBMT) using low-level laser influences the release of several growth factors involved in the formation of epithelial cells, fibroblasts, collagen and vascular proliferation, besides accelerating the synthesis of bone matrix due to the increased vascularization and lower inflammatory response, with significant increase of osteocytes in the irradiated bone. Considering its properties, beneficial effects and clinical relevance, the aim of this review was to analyze the scientific literature regarding the use of PBMT in the process of bone defect repair. METHODS: Electronic search was carried out in PubMed/MEDLINEⓇ and Web of Science databases with combination of the descriptors low-level laser therapy AND bone repair, considering the period of publication until the year 2018. RESULTS: The literature search identified 254 references in PubMed/MEDLINE and 204 in Web of Science, of which 33 and 4 were selected, respectively, in accordance with the eligibility requirements. The analysis of researches showed articles using PBMT in several places of experimentation in the subjects, different types of associated biomaterials, stimulatory effects on cell proliferation, besides variations in the parameters of use of laser therapy, mainly in relation to the wavelength and density of energy. Only four articles reported that the laser did not improve the osteogenic properties of a biomaterial. CONCLUSIONS: Many studies have shown that PBMT has positive photobiostimulatory effects on bone regeneration, accelerating its process regardless of parameters and the use of biomaterials. However, standardization of its use is still imperfect and should be better studied to allow correct application concerning the utilization protocols.
BACKGROUND: Photobiomodulation therapy (PBMT) using low-level laser influences the release of several growth factors involved in the formation of epithelial cells, fibroblasts, collagen and vascular proliferation, besides accelerating the synthesis of bone matrix due to the increased vascularization and lower inflammatory response, with significant increase of osteocytes in the irradiated bone. Considering its properties, beneficial effects and clinical relevance, the aim of this review was to analyze the scientific literature regarding the use of PBMT in the process of bone defect repair. METHODS: Electronic search was carried out in PubMed/MEDLINEⓇ and Web of Science databases with combination of the descriptors low-level laser therapy AND bone repair, considering the period of publication until the year 2018. RESULTS: The literature search identified 254 references in PubMed/MEDLINE and 204 in Web of Science, of which 33 and 4 were selected, respectively, in accordance with the eligibility requirements. The analysis of researches showed articles using PBMT in several places of experimentation in the subjects, different types of associated biomaterials, stimulatory effects on cell proliferation, besides variations in the parameters of use of laser therapy, mainly in relation to the wavelength and density of energy. Only four articles reported that the laser did not improve the osteogenic properties of a biomaterial. CONCLUSIONS: Many studies have shown that PBMT has positive photobiostimulatory effects on bone regeneration, accelerating its process regardless of parameters and the use of biomaterials. However, standardization of its use is still imperfect and should be better studied to allow correct application concerning the utilization protocols.
Authors: Daiane Domingos de Barros; Josefa Simere Dos Santos Barros Catão; Alieny Cristina Duarte Ferreira; Thamyres Maria Silva Simões; Renata de Albuquerque Cavalcanti Almeida; Maria Helena Chaves de Vasconcelos Catão Journal: Lasers Med Sci Date: 2022-01-11 Impact factor: 3.161
Authors: Marcelo de Azevedo E Sousa Munhoz; Karina Torres Pomini; Ana Maria de Guzzi Plepis; Virginia da Conceição Amaro Martins; Eduardo Gomes Machado; Renato de Moraes; Fernando Bento Cunha; Arnaldo Rodrigues Santos Junior; Guinea Brasil Camargo Cardoso; Marco Antonio Hungaro Duarte; Murilo Priori Alcalde; Daniela Vieira Buchaim; Rogerio Leone Buchaim; Marcelo Rodrigues da Cunha Journal: PLoS One Date: 2020-04-20 Impact factor: 3.240
Authors: Iris Jasmin Santos German; Karina Torres Pomini; Ana Carolina Cestari Bighetti; Jesus Carlos Andreo; Carlos Henrique Bertoni Reis; André Luis Shinohara; Geraldo Marco Rosa Júnior; Daniel de Bortoli Teixeira; Marcelie Priscila de Oliveira Rosso; Daniela Vieira Buchaim; Rogério Leone Buchaim Journal: Materials (Basel) Date: 2020-02-04 Impact factor: 3.623