Literature DB >> 315847

PHA-induced soluble factor(s) can activate B-cells from patients with chronic lymphatic leukaemia.

K H Robert.   

Abstract

Blood lymphocytes from eight patients with chronic lymphatic leukaemia (CLL) were stimulated by phytohaemagglutinin (PHA). The effect was defined as a pronounced increase of 3H-thymidine incorporation, and a concomitant blast transformation of a large portion of surface Ig-positive, E-rosette-forming (E-RFC) negative cells. E-RFC depletion reduced these effects to nearly background levels, and the pooled data strongly suggest that malignant B-lymphocytes in CLL are capable of responding to a PHA-induced T cell factor. A possible use for this factor in characterizing different subpopulations of CLL cells is discussed.

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Year:  1979        PMID： 315847      PMCID： PMC1537779     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  8 in total

Review 1.  Functional analysis of B cell heterogeneity.

Authors:  E Gronowicz; A Coutinho
Journal:  Transplant Rev       Date:  1975

2.  Further characterization of the circulating cell in chronic lymphocytic leukemia.

Authors:  E F Schultz; S Davis; A D Rubin
Journal:  Blood       Date:  1976-08       Impact factor: 22.113

3.  [Lymphocyte in chronic lymphatic leukemia].

Authors:  G Brittinger; W Augener; K Bremer; G Cohnen; S Dabag; K Fischer; E König; P Meusers
Journal:  Blut       Date:  1975-05

4.  B-cell activation of peripheral blood lymphocytes from patients with chronic lymphatic leukaemia.

Authors:  K H Robèrt; E Möller; G Gahrton; H Eriksson; B Nilsson
Journal:  Clin Exp Immunol       Date:  1978-08       Impact factor: 4.330

5.  Modification of the response of human T lymphocytes to phytomitogens by cocultivation with unresponsive non-T leukocytes.

Authors:  H Blomgren
Journal:  Scand J Immunol       Date:  1976       Impact factor: 3.487

6.  Receptors for Helix pomatia A haemagglutinin on leukaemic lymphocytes from patients with chronic lymphocytic leukaemia (CLL).

Authors:  U Hellstrom; H Mellstedt; P Perlmann; G Holm; D PETTERSSON
Journal:  Clin Exp Immunol       Date:  1976-11       Impact factor: 4.330

7.  Activation of human lymphocyte subpopulations by rabbit anti-human beta2-microglobulin and by lipopolysaccharide.

Authors:  O Ringdén
Journal:  Scand J Immunol       Date:  1976       Impact factor: 3.487

8.  Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.

Authors:  M Jondal; G Holm; H Wigzell
Journal:  J Exp Med       Date:  1972-08-01       Impact factor: 14.307
  8 in total
  5 in total

1.  Stimulation of chronic lymphatic leukaemia cells by pokeweed mitogen after treatment with neuraminidase-galactose oxidase.

Authors:  M N Zafar; S Pittman; M Cherchi; D Catovsky
Journal:  Clin Exp Immunol       Date:  1981-04       Impact factor: 4.330

2.  The roles of leukaemic and residual normal cells in the proliferative response of chronic lymphocytic leukaemic lymphocytes to mitogens.

Authors:  A P Johnstone; R E Millard; L Hudson
Journal:  Clin Exp Immunol       Date:  1982-03       Impact factor: 4.330

3.  Stimulation of T lymphocytes by protein A from Staphylococcus aureus in B-derived chronic lymphocytic leukaemia.

Authors:  P Guglielmi; J L Preud'Homme
Journal:  Clin Exp Immunol       Date:  1980-07       Impact factor: 4.330

4.  Polyclonal human T lymphocyte activation results in the secondary functional activation of the human B lymphocyte.

Authors:  A G Bird; L Hammarström; C I Smith; S Britton
Journal:  Clin Exp Immunol       Date:  1981-01       Impact factor: 4.330

5.  Mitogenic stimulation of malignant B cells. Chronic lymphocytic leukaemia: relationship between stimulation and surface phenotype.

Authors:  A C Bloem; E J Bast; F H Gmelig Meyling; G C DeGast; R E Ballieux
Journal:  Clin Exp Immunol       Date:  1982-11       Impact factor: 4.330
  5 in total

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