Literature DB >> 31584577

Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity.

Junjie Fu1, Jing Han2, Tingting Meng1, Jing Hu3, Jian Yin1.   

Abstract

A novel type of hydrogen peroxide (H2O2)-activated diazeniumdiolate based on an α-ketoamide moietey was developed as a nitric oxide (NO) donor. KA-NO-4 inhibited lung cancer cells with submicromolar activity. The H2O2-responsive behaviour of KA-NO-4 was thoroughly investigated. The NO-centered mechanism of action of KA-NO-4 was intracellularly studied.

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Year:  2019        PMID： 31584577     DOI： 10.1039/c9cc05266f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

Review 1.  Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review).

Authors:  Abbas Salihi; Mohammed A Al-Naqshabandi; Zhikal Omar Khudhur; Zjwan Housein; Harmand A Hama; Ramyar M Abdullah; Bashdar Mahmud Hussen; Twana Alkasalias
Journal:  Mol Med Rep       Date:  2022-05-26       Impact factor: 3.423

2.  Nitric Oxide as a Potential Adjuvant Therapeutic for Neuroblastoma: Effects of NO on Murine N2a Cells.

Authors:  Jenna L Gordon; Melissa M Reynolds; Mark A Brown
Journal:  Vet Sci       Date:  2020-04-23

3.  Direct oxidation of N-ynylsulfonamides into N-sulfonyloxoacetamides with DMSO as a nucleophilic oxidant.

Authors:  Jun Dong; Duo Fu; Dongning Sheng; Jiayi Wang; Jiaxi Xu
Journal:  RSC Adv       Date:  2021-12-20       Impact factor: 4.036

Review 4.  Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications.

Authors:  Gina Tavares; Patrícia Alves; Pedro Simões
Journal:  Pharmaceutics       Date:  2022-06-29       Impact factor: 6.525
  4 in total

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