Literature DB >> 31583677

Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice.

Mohsen Khosravi-Maharlooei1, Markus Hoelzl1, Hao Wei Li1, Rachel C Madley1,2, Elizabeth E Waffarn1, Nichole M Danzl1, Megan Sykes1,2,3.   

Abstract

We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune system mice. Removing the native mouse thymus is critical for studies of human thymopiesis in grafted thymic tissue in humanized mice.
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Hematopoietic stem cells; Humanized mice; NSG mice; Thymectomy; Thymopoiesis

Mesh：

Year:  2019        PMID： 31583677      PMCID： PMC6940512          DOI： 10.1002/eji.201948205

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   6.688


  14 in total

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Journal:  Br J Haematol       Date:  1960-07       Impact factor: 6.998

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Journal:  Science       Date:  1989-08-18       Impact factor: 47.728

6.  A model for personalized in vivo analysis of human immune responsiveness.

Authors:  Hannes Kalscheuer; Nichole Danzl; Takashi Onoe; Ted Faust; Robert Winchester; Robin Goland; Ellen Greenberg; Thomas R Spitzer; David G Savage; Hiroyuki Tahara; Goda Choi; Yong-Guang Yang; Megan Sykes
Journal:  Sci Transl Med       Date:  2012-03-14       Impact factor: 17.956

7.  Memory CD8+ T cells support the maintenance of hematopoietic stem cells in the bone marrow.

Authors:  Sulima Geerman; Giso Brasser; Sudeep Bhushal; Fiamma Salerno; Natasja A Kragten; Mark Hoogenboezem; Gerald de Haan; Monika C Wolkers; María Fernanda Pascutti; Martijn A Nolte
Journal:  Haematologica       Date:  2018-02-22       Impact factor: 9.941

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Authors:  J F MILLER
Journal:  Br Med J       Date:  1963-08-24

9.  Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

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Journal:  J Exp Med       Date:  1996-08-01       Impact factor: 14.307

10.  A Humanized Mouse Model Generated Using Surplus Neonatal Tissue.

Authors:  Matthew E Brown; Ying Zhou; Brian E McIntosh; Ian G Norman; Hannah E Lou; Mitch Biermann; Jeremy A Sullivan; Timothy J Kamp; James A Thomson; Petros V Anagnostopoulos; William J Burlingham
Journal:  Stem Cell Reports       Date:  2018-03-22       Impact factor: 7.765
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  7 in total

Review 1.  Humanized Mouse Models for Evaluation of PSC Immunogenicity.

Authors:  Jack Hermsen; Matthew E Brown
Journal:  Curr Protoc Stem Cell Biol       Date:  2020-09

2.  Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs.

Authors:  Grace Nauman; Nichole M Danzl; Jaeyop Lee; Chiara Borsotti; Rachel Madley; Jianing Fu; Markus A Hölzl; Alexander Dahmani; Akaitz Dorronsoro Gonzalez; Éstefania Chavez; Sean R Campbell; Suxiao Yang; Prakash Satwani; Kang Liu; Megan Sykes
Journal:  J Immunol       Date:  2022-03-21       Impact factor: 5.422

3.  Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus.

Authors:  Rafael Gras-Peña; Nichole M Danzl; Mohsen Khosravi-Maharlooei; Sean R Campbell; Amanda E Ruiz; Christopher A Parks; William Meng Suen Savage; Markus A Holzl; Debanjana Chatterjee; Megan Sykes
Journal:  J Allergy Clin Immunol       Date:  2021-10-22       Impact factor: 14.290

Review 4.  High Throughput Human T Cell Receptor Sequencing: A New Window Into Repertoire Establishment and Alloreactivity.

Authors:  Jianing Fu; Mohsen Khosravi-Maharlooei; Megan Sykes
Journal:  Front Immunol       Date:  2021-11-05       Impact factor: 7.561

Review 5.  Towards gene therapy for IPEX syndrome.

Authors:  Simon Borna; Esmond Lee; Yohei Sato; Rosa Bacchetta
Journal:  Eur J Immunol       Date:  2022-04-13       Impact factor: 6.688

6.  Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.

Authors:  Mohsen Khosravi-Maharlooei; HaoWei Li; Markus Hoelzl; Guiling Zhao; Amanda Ruiz; Aditya Misra; Yang Li; Nato Teteloshvili; Grace Nauman; Nichole Danzl; Xiaolan Ding; Elisha Y Pinker; Aleksandar Obradovic; Yong-Guang Yang; Alina Iuga; Remi J Creusot; Robert Winchester; Megan Sykes
Journal:  J Autoimmun       Date:  2021-02-19       Impact factor: 14.511

7.  Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus.

Authors:  Rachel Madley; Grace Nauman; Nichole Danzl; Chiara Borsotti; Mohsen Khosravi Maharlooei; Hao Wei Li; Estefania Chavez; Remi J Creusot; Maki Nakayama; Bart Roep; Megan Sykes
Journal:  J Transl Autoimmun       Date:  2020-08-09
  7 in total

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