Rong-Jian Lu1,2, Xing Wang3, Hui-Xia He2, Ling-Ling E2, Ying Li4, Gui-Lan Zhang2, Chuan-Jie Li2, Cheng-Yun Ning4, Hong-Chen Liu5. 1. Department of Stomatology, the Fifth Medical Center, Chinese PLA General Hospital, 100071, Beijing, China. 2. Department of Stomatology, the First Medical Center, Chinese PLA General Hospital, 100853, Beijing, China. 3. Shanxi Medical University School and Hospital of Stomatology, 030001, Taiyuan, China. 4. School of Materials Science and Technology, South China University of Technology, 510641, Guangzhou, China. 5. Department of Stomatology, the First Medical Center, Chinese PLA General Hospital, 100853, Beijing, China. liu-hc301@hotmail.com.
Abstract
OBJECTIVE: The fabrication of bioactive coatings on metallic implants to enhance osseointegration has become a topic of general interest in orthopedics and dentistry. Hydroxyapatite (HA) coating has been shown to induce bone formation and promote bone-implant integration. Unfortunately, poor mechanical performance has hindered this from becoming a favorable coating material. The majority of present studies have focused in incorporating different elements into HA coatings to improve mechanical properties. In recent years, tantalum (Ta) has received increasing attention due to its excellent biocompatibility and corrosion resistance. The aim of on the present study was to investigate the fabrication and biological performance of Ta-incorporated HA coatings. METHODS: Ta-incorporated HA coatings were fabricated using the plasma spray technique on a titanium substrate, and the surface characteristics and mechanical properties were examined. In addition, the effects of Ta-incorporated HA coatings on the biological behavior of mesenchymal stem cells (BMSCs) were investigated. RESULTS: Ta-incorporated HA coatings with microporous structure had higher roughness and wettability. In addition, the bonding strength of Ta/HA coatings with the substrate was substantially superior to HA coatings. Furthermore, Ta-incorporated HA coatings not only facilitated initial cell adhesion and faster proliferation, but also promoted the osteogenic differentiation of BMSCs. CONCLUSION: These results indicate that the incorporation of Ta could improve mechanical performance and increase the osteogenic activity of HA coatings. The Ta-incorporated HA coating fabricated by plasma spraying is expected to be a promising bio-coating material for metallic implants.
OBJECTIVE: The fabrication of bioactive coatings on metallic implants to enhance osseointegration has become a topic of general interest in orthopedics and dentistry. Hydroxyapatite (HA) coating has been shown to induce bone formation and promote bone-implant integration. Unfortunately, poor mechanical performance has hindered this from becoming a favorable coating material. The majority of present studies have focused in incorporating different elements into HA coatings to improve mechanical properties. In recent years, tantalum (Ta) has received increasing attention due to its excellent biocompatibility and corrosion resistance. The aim of on the present study was to investigate the fabrication and biological performance of Ta-incorporated HA coatings. METHODS:Ta-incorporated HA coatings were fabricated using the plasma spray technique on a titanium substrate, and the surface characteristics and mechanical properties were examined. In addition, the effects of Ta-incorporated HA coatings on the biological behavior of mesenchymal stem cells (BMSCs) were investigated. RESULTS:Ta-incorporated HA coatings with microporous structure had higher roughness and wettability. In addition, the bonding strength of Ta/HA coatings with the substrate was substantially superior to HA coatings. Furthermore, Ta-incorporated HA coatings not only facilitated initial cell adhesion and faster proliferation, but also promoted the osteogenic differentiation of BMSCs. CONCLUSION: These results indicate that the incorporation of Ta could improve mechanical performance and increase the osteogenic activity of HA coatings. The Ta-incorporated HA coating fabricated by plasma spraying is expected to be a promising bio-coating material for metallic implants.
Authors: Julietta V Rau; Ilaria Cacciotti; Sara Laureti; Marco Fosca; Gaspare Varvaro; Alessandro Latini Journal: J Biomed Mater Res B Appl Biomater Date: 2014-12-30 Impact factor: 3.368
Authors: A Thorfve; C Lindahl; W Xia; K Igawa; A Lindahl; P Thomsen; A Palmquist; P Tengvall Journal: Acta Biomater Date: 2013-12-14 Impact factor: 8.947
Authors: Chengrong Kang; Yudong Wang; Liang Li; Zhangwei Li; Qianbing Zhou; Xuan Pan Journal: J Mater Sci Mater Med Date: 2021-10-23 Impact factor: 3.896