Literature DB >> 3158314

Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes.

D Kirsch, B Obermaier, H U Häring.   

Abstract

The C-kinase activating phorbolester TPA (12-O-Tetradecanoyl-beta-phorbol-13-acetate) and PdBu (4-beta-Phorbol-12,13,dibutyrate) stimulated D-glucose transport twofold in isolated rat adipocytes but inhibited high affinity insulin binding and the responsiveness of D-glucose transport to insulin stimulation by about 30%. Phorbolesters have therefore insulin-like effects but antagonize insulin on receptor and postreceptor level.

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Year:  1985        PMID： 3158314     DOI： 10.1016/0006-291x(85)90121-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  19 in total

1.  The translocation of the glucose transporter sub-types GLUT1 and GLUT4 in isolated fat cells is differently regulated by phorbol esters.

Authors:  B Vogt; J Mushack; E Seffer; H U Häring
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857

Review 2.  Role of kinases in insulin stimulation of glucose transport.

Authors:  A Klip; A G Douen
Journal:  J Membr Biol       Date:  1989-10       Impact factor: 1.843

3.  Effects of phorbol ester on immunoreactive protein kinase C, insulin binding, and glucose uptake in astrocytic glial and neuronal cells from the brain.

Authors:  L M Mudd; M K Raizada
Journal:  Neurochem Res       Date:  1990-03       Impact factor: 3.996

4.  Protein kinase C activators selectively inhibit insulin-stimulated system A transport activity in skeletal muscle at a post-receptor level.

Authors:  A Gumà; M Camps; M Palacín; X Testar; A Zorzano
Journal:  Biochem J       Date:  1990-06-15       Impact factor: 3.857

Review 5.  The insulin receptor: signalling mechanism and contribution to the pathogenesis of insulin resistance.

Authors:  H U Häring
Journal:  Diabetologia       Date:  1991-12       Impact factor: 10.122

Review 6.  The regulation of glucose transport in insulin-sensitive cells.

Authors:  H G Joost; T M Weber
Journal:  Diabetologia       Date:  1989-12       Impact factor: 10.122

7.  Protein kinase C is not required for insulin stimulation of hexose uptake in muscle cells in culture.

Authors:  A Klip; T Ramlal
Journal:  Biochem J       Date:  1987-02-15       Impact factor: 3.857

8.  Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol ester-stimulated glucose transport in in vitro incubated human muscle strips.

Authors:  J R Zierath; D Galuska; A Engström; K H Johnson; C Betsholtz; P Westermark; H Wallberg-Henriksson
Journal:  Diabetologia       Date:  1992-01       Impact factor: 10.122

9.  Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.

Authors:  J Smal; P De Meyts
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

10.  Decreased tyrosine kinase activity of insulin receptor isolated from rat adipocytes rendered insulin-resistant by catecholamine treatment in vitro.

Authors:  H Häring; D Kirsch; B Obermaier; B Ermel; F Machicao
Journal:  Biochem J       Date:  1986-02-15       Impact factor: 3.857
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