Indication for intervention in patients with renovascular hypertension.

It is now possible to accurately identify patients with renovascular hypertension who need renal angioplasty or revascularization. Evaluation does not require hospitalization and begins with the determination of an ambulatory plasma renin activity (PRA) indexed against sodium excretion and a captopril test. Subsequently differential renal vein renins with matching inferior vena caval (IVC) renins are measured often with converting enzyme inhibition. Identifying criteria are as follows: (1) high PRA indexed against sodium excretion, (2) hypersecretion of renin following captopril administration, (3) absence of renin secretion from the contralateral kidney, and (4) an ipsilateral renal vein renin increment at least 50% greater than the matching IVC renin. Patients who meet the criteria are admitted for percutaneous transluminal renal angioplasty.