Literature DB >> 31581343

The role of innate immunity in asthma development and protection: Lessons from the environment.

Vadim Pivniouk1,2, Joao Antonio Gimenes Junior1, Linnea K Honeker1, Donata Vercelli1,2.   

Abstract

Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen-induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review.
© 2019 John Wiley & Sons Ltd.

Entities:  

Keywords:  asthma; environment; farm effect; hygiene hypothesis; innate immunity; microbiome

Mesh：

Substances：

Year:  2020        PMID： 31581343     DOI： 10.1111/cea.13508

Source DB:  PubMed          Journal:  Clin Exp Allergy        ISSN： 0954-7894            Impact factor:   5.018


  8 in total

1.  Mouse Models of Asthma: Characteristics, Limitations and Future Perspectives on Clinical Translation.

Authors:  Tolga Akkoc; Liam O'Mahony; Ruth Ferstl; Cezmi Akdis; Tunc Akkoc
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

2.  Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis.

Authors:  Vadim Pivniouk; Joao A Gimenes-Junior; Peace Ezeh; Ashley Michael; Oksana Pivniouk; Seongmin Hahn; Sydney R VanLinden; Sean P Malone; Amir Abidov; Dayna Anderson; Justyna Gozdz; Avery DeVries; Fernando D Martinez; Christian Pasquali; Donata Vercelli
Journal:  J Allergy Clin Immunol       Date:  2021-09-22       Impact factor: 10.793

Review 3.  Pulmonary neuroendocrine cells: physiology, tissue homeostasis and disease.

Authors:  Masafumi Noguchi; Kana T Furukawa; Mitsuru Morimoto
Journal:  Dis Model Mech       Date:  2020-12-21       Impact factor: 5.758

Review 4.  The Hygiene Hypothesis - Learning From but Not Living in the Past.

Authors:  Petra I Pfefferle; Corinna U Keber; Robert M Cohen; Holger Garn
Journal:  Front Immunol       Date:  2021-03-16       Impact factor: 7.561

5.  Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling.

Authors:  Anna-Dorothea Gorki; Sylvia Knapp; Sophie Zahalka; Philipp Starkl; Martin L Watzenboeck; Asma Farhat; Mariem Radhouani; Florian Deckert; Anastasiya Hladik; Karin Lakovits; Felicitas Oberndorfer; Caroline Lassnig; Birgit Strobl; Kristaps Klavins; Mai Matsushita; David E Sanin; Katarzyna M Grzes; Edward J Pearce
Journal:  Mucosal Immunol       Date:  2022-07-18       Impact factor: 8.701

Review 6.  NOD-like receptors in asthma.

Authors:  Daniel Alvarez-Simon; Saliha Ait Yahia; Patricia de Nadai; Camille Audousset; Mathias Chamaillard; Ivo Gomperts Boneca; Anne Tsicopoulos
Journal:  Front Immunol       Date:  2022-09-14       Impact factor: 8.786

7.  Crucial role of stimulator of interferon genes-dependent signaling in house dust mite extract-induced IgE production.

Authors:  Hiroki Nunokawa; Yusuke Murakami; Takashi Ishii; Tomoya Narita; Haruyuki Ishii; Hajime Takizawa; Naomi Yamashita
Journal:  Sci Rep       Date:  2021-06-23       Impact factor: 4.379

Review 8.  Microbiota and human allergic diseases: the company we keep.

Authors:  Donata Vercelli
Journal:  Curr Opin Immunol       Date:  2021-06-26       Impact factor: 7.268
  8 in total

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