Literature DB >> 3158075

DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes.

S Lewis, A Gifford, D Baltimore.   

Abstract

Immunoglobulin K genes are constructed during lymphocyte differentiation by the joining of two DNA elements, VK and JK, to form both a VKJK coding unit and a reciprocal recombination product. The two products formed in single VK-to-JK joining events can be directly isolated through the use of a retrovirally introduced recombination substrate. The structural analysis of a number of recombinants and the derivation of secondary recombination products define some of the basic features of the mechanism of immunoglobulin gene assembly.

Mesh：

Substances：

Year:  1985        PMID： 3158075     DOI： 10.1126/science.3158075

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  49 in total

1.  Wild-type V(D)J recombination in scid pre-B cells.

Authors:  E A Hendrickson; M S Schlissel; D T Weaver
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

2.  Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

Authors:  S Kallenbach; N Doyen; M Fanton d'Andon; F Rougeon
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

3.  Genomic instability due to V(D)J recombination-associated transposition.

Authors:  Yeturu V R Reddy; Eric J Perkins; Dale A Ramsden
Journal:  Genes Dev       Date:  2006-06-15       Impact factor: 11.361

4.  V(D)J recombination: evidence that a replicative mechanism is not required.

Authors:  C L Hsieh; R P McCloskey; E Radany; M R Lieber
Journal:  Mol Cell Biol       Date:  1991-08       Impact factor: 4.272

5.  Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

Authors:  H P Brezinschek; S J Foster; R I Brezinschek; T Dörner; R Domiati-Saad; P E Lipsky
Journal:  J Clin Invest       Date:  1997-05-15       Impact factor: 14.808

6.  Comparison of filler DNA at immune, nonimmune, and oncogenic rearrangements suggests multiple mechanisms of formation.

Authors:  D B Roth; X B Chang; J H Wilson
Journal:  Mol Cell Biol       Date:  1989-07       Impact factor: 4.272

7.  Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

Authors:  M R Lieber; J E Hesse; K Mizuuchi; M Gellert
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

8.  Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferase.

Authors:  H Narimatsu; S Sinha; K Brew; H Okayama; P K Qasba
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

9.  Rescue of chromosomal T-antigen sequences onto extrachromosomally replicating, defective simian virus 40 DNA by homologous recombination.

Authors:  S Subramani
Journal:  Mol Cell Biol       Date:  1986-04       Impact factor: 4.272

10.  Evolution of immunoglobulin heavy chain variable region genes: a VH family can last for 150-200 million years or longer.

Authors:  E Andersson; T Matsunaga
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.