Literature DB >> 31580738

Molecular Basis Underlying Host Immunity Subversion by Mycobacterium tuberculosis PE/PPE Family Molecules.

Xiaowen Yu1, Jing Feng1, Lu Huang2, Hongyan Gao1, Jinkun Liu1, Shutong Bai1, Bin Wu1, Jianping Xie3.   

Abstract

Mycobacterium tuberculosis proline-glutamic acid (PE)/proline-proline-glutamic acid (PPE) family proteins, with >160 members, are crucial for virulence, cell wall, host cell fate, host Th1/Th2 balance, and CD8+ T cell recognition. Ca2+ signaling is involved in PE/PPE protein-mediated host-pathogen interaction. PE/PPE proteins also function in heme utilization and nitric oxide production. PE/PPE family proteins are intensively pursued as diagnosis biomarkers and vaccine components.

Entities:  

Keywords:  Mycobacterium tuberculosis; PE/PPE proteins; diagnosis biomarker; host immunity; vaccine

Mesh：

Substances：

Year:  2019        PMID： 31580738     DOI： 10.1089/dna.2019.4852

Source DB:  PubMed          Journal:  DNA Cell Biol        ISSN： 1044-5498            Impact factor:   3.311


  5 in total

1.  BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis.

Authors:  Sangeeta Tiwari; Taru S Dutt; Bing Chen; Mei Chen; John Kim; Annie Zhi Dai; Regy Lukose; Crystal Shanley; Amy Fox; Burton R Karger; Steven A Porcelli; John Chan; Brendan K Podell; Andres Obregon-Henao; Ian M Orme; William R Jacobs; Marcela Henao-Tamayo
Journal:  Vaccine       Date:  2020-09-23       Impact factor: 3.641

2.  Protein Integrated Network Analysis to Reveal Potential Drug Targets Against Extended Drug-Resistant Mycobacterium tuberculosis XDR1219.

Authors:  Noor Ul Ain Zahra; Faiza Jamil; Reaz Uddin
Journal:  Mol Biotechnol       Date:  2021-08-11       Impact factor: 2.695

Review 3.  Role of the PE/PPE Family in Host-Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool Design.

Authors:  Jianing Qian; Run Chen; Honghai Wang; Xuelian Zhang
Journal:  Front Cell Infect Microbiol       Date:  2020-11-26       Impact factor: 5.293

Review 4.  The Mycobacterium tuberculosis PE_PGRS Protein Family Acts as an Immunological Decoy to Subvert Host Immune Response.

Authors:  Tarina Sharma; Anwar Alam; Aquib Ehtram; Anshu Rani; Sonam Grover; Nasreen Z Ehtesham; Seyed E Hasnain
Journal:  Int J Mol Sci       Date:  2022-01-04       Impact factor: 5.923

5.  Mycobacterium tuberculosis PE31 (Rv3477) Attenuates Host Cell Apoptosis and Promotes Recombinant M. smegmatis Intracellular Survival via Up-regulating GTPase Guanylate Binding Protein-1.

Authors:  Md Kaisar Ali; Gong Zhen; Lambert Nzungize; Andrea Stojkoska; Xiangke Duan; Chunyan Li; Wei Duan; Junqi Xu; Jianping Xie
Journal:  Front Cell Infect Microbiol       Date:  2020-02-07       Impact factor: 5.293
  5 in total

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