| Literature DB >> 31580480 |
Rahel Frick1,2, Kristin Støen Gunnarsen1,2, Shiva Dahal-Koirala1,3, Louise Fremgaard Risnes1,3, Ludvig M Sollid1,3, Inger Sandlie1,2, Lene Støkken Høydahl1,2,3, Geir Åge Løset2,4.
Abstract
The semi-public T-cell response towards the gluten epitope DQ2.5-glia-α2 uses a prototypic TCR encoded by the germline segments TRAV26-1 and TRBV7-2. Through mutagenesis experiments, we show that a TRAV26-1encoded recognition motif contacts the MHC β-chain and the TCR CDR3β loop underpinning this conserved T-cell response restricted to the prototypic TCRs.Entities:
Keywords: Celiac disease; Repertoire bias; TCR; TRAV26-1; pMHC recognition
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Year: 2019 PMID： 31580480 DOI： 10.1002/eji.201948235
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532