| Literature DB >> 31580341 |
Ajesh P Thomas1, An-Jung Lee2, L Palanikumar1, Batakrishna Jana1, Kibeom Kim1, Sangpil Kim1, Haewon Ok1, Jihoon Seol1, Dongseok Kim1, Byoung Heon Kang2, Ja-Hyoung Ryu1.
Abstract
Mitochondria targeting sensitizers are continuing to gain importance in photodynamic therapy (PDT). Members of the 90 kDa heat shock protein (Hsp90) family, including TRAP1 (Hsp75), are overexpressed in cancer cells and help to control the antiapoptotic protein activity. The present work introduces an Hsp90 inhibitor-mitochondria targeting indocyanine dye conjugate (IR-PU) for high PDT efficacy.Entities:
Year: 2019 PMID： 31580341 DOI： 10.1039/c9cc06411g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222