L Morris1, S Hiasihri2, G Chan2, A Honjepari1, O Tugo3, M Taune3, P Aia4, P Dakulala4, S S Majumdar2. 1. Western Province Health Department, Daru, Western Province, Papua New Guinea (PNG). 2. Burnet Institute, Melbourne, Victoria, Australia. 3. Daru General Hospital, Daru, Western Province, PNG. 4. National Department of Health, Port Morseby, PNG.
Abstract
SETTING: A response to an outbreak of multidrug-resistant tuberculosis (MDR-TB) on Daru Island, South Fly District (SFD), Western Province, Papua New Guinea (PNG) was implemented by a national emergency response taskforce. OBJECTIVE: To describe programmatic interventions for TB in SFD and evaluate characteristics of TB case notifications, drug resistance and treatment outcomes. DESIGN: This was a retrospective cohort study based on routine programmatic data for all patients enrolled on TB treatment at Daru General Hospital from 2014 to 2017. RESULTS: The response involved high-level political commitment, joint planning, resource mobilisation, community engagement and strengthening TB case detection and treatment. Of 1548 people enrolled on TB treatment, 1208 (78%) had drug-susceptible TB (DS-TB) and 333 (21.5%) had MDR-TB. There was an increase in MDR-TB as a proportion of all TB. Treatment success rates increased over the study period from 55% to 86% for DS-TB, and from 70% to 81% for MDR-TB from 2014 to 2015. The 2014 case notification rate for TB in SFD was 1031/100 000, decreasing to 736/100 000 in 2017. CONCLUSION: The outbreak was stabilised through the response from the national and provincial governments and international partners. Additional interventions are needed to decrease the TB burden in Daru.
SETTING: A response to an outbreak of multidrug-resistant tuberculosis (MDR-TB) on Daru Island, South Fly District (SFD), Western Province, Papua New Guinea (PNG) was implemented by a national emergency response taskforce. OBJECTIVE: To describe programmatic interventions for TB in SFD and evaluate characteristics of TB case notifications, drug resistance and treatment outcomes. DESIGN: This was a retrospective cohort study based on routine programmatic data for all patients enrolled on TB treatment at Daru General Hospital from 2014 to 2017. RESULTS: The response involved high-level political commitment, joint planning, resource mobilisation, community engagement and strengthening TB case detection and treatment. Of 1548 people enrolled on TB treatment, 1208 (78%) had drug-susceptible TB (DS-TB) and 333 (21.5%) had MDR-TB. There was an increase in MDR-TB as a proportion of all TB. Treatment success rates increased over the study period from 55% to 86% for DS-TB, and from 70% to 81% for MDR-TB from 2014 to 2015. The 2014 case notification rate for TB in SFD was 1031/100 000, decreasing to 736/100 000 in 2017. CONCLUSION: The outbreak was stabilised through the response from the national and provincial governments and international partners. Additional interventions are needed to decrease the TB burden in Daru.
Authors: Neel R Gandhi; Darren Weissman; Prashini Moodley; Melissa Ramathal; Inga Elson; Barry N Kreiswirth; Barun Mathema; Elena Shashkina; Richard Rothenberg; Anthony P Moll; Gerald Friedland; A Willem Sturm; N Sarita Shah Journal: J Infect Dis Date: 2012-11-19 Impact factor: 5.226
Authors: D Falzon; E Jaramillo; H J Schünemann; M Arentz; M Bauer; J Bayona; L Blanc; J A Caminero; C L Daley; C Duncombe; C Fitzpatrick; A Gebhard; H Getahun; M Henkens; T H Holtz; J Keravec; S Keshavjee; A J Khan; R Kulier; V Leimane; C Lienhardt; C Lu; A Mariandyshev; G B Migliori; F Mirzayev; C D Mitnick; P Nunn; G Nwagboniwe; O Oxlade; D Palmero; P Pavlinac; M I Quelapio; M C Raviglione; M L Rich; S Royce; S Rüsch-Gerdes; A Salakaia; R Sarin; D Sculier; F Varaine; M Vitoria; J L Walson; F Wares; K Weyer; R A White; M Zignol Journal: Eur Respir J Date: 2011-08-04 Impact factor: 16.671
Authors: S Bamrah; R Brostrom; F Dorina; L Setik; R Song; L M Kawamura; A Heetderks; S Mase Journal: Int J Tuberc Lung Dis Date: 2014-08 Impact factor: 2.373
Authors: Christopher M Gilpin; Graham Simpson; Stephen Vincent; Terry P O'Brien; Trevor A Knight; Maria Globan; Christopher Coulter; Anastasios Konstantinos Journal: Med J Aust Date: 2008-02-04 Impact factor: 7.738
Authors: Arnold Bainomugisa; Evelyn Lavu; Stenard Hiashiri; Suman Majumdar; Alice Honjepari; Rendi Moke; Paison Dakulala; Grant A Hill-Cawthorne; Sushil Pandey; Ben J Marais; Chris Coulter; Lachlan Coin Journal: Microb Genom Date: 2018-01-04
Authors: Paul Aia; Margaret Kal; Evelyn Lavu; Lucy N John; Karen Johnson; Chris Coulter; Julia Ershova; Olga Tosas; Matteo Zignol; Shalala Ahmadova; Tauhid Islam Journal: PLoS One Date: 2016-03-22 Impact factor: 3.240
Authors: Paul Aia; Lungten Wangchuk; Fukushi Morishita; Jacob Kisomb; Robin Yasi; Margaret Kal; Tauhid Islam Journal: Western Pac Surveill Response J Date: 2018-06-15
Authors: Joseph Baruch Baluku; Richard Katuramu; Joshua Naloka; Enock Kizito; Martin Nabwana; Felix Bongomin Journal: BMC Pulm Med Date: 2021-07-10 Impact factor: 3.317