Literature DB >> 315789

Generation of factor VIII coagulant activity by isolated, perfused neonatal pig livers and adult rat livers.

C A Owen, E J Bowie, D N Fass.   

Abstract

Isolated, normal, neonatal pig livers released VIII:C into perfusates of porcine von Willebrand blood lacking VIIIR:AG and VIII:RWF. Neonatal von Willebrand livers released VIII:C only when partially purified VIIIR:AG was added to the von Willbrand blood. Adult rat livers, perfused with frozen-thawed erythrocytes suspended in Tyrode's solution containing 6% bovine serum albumin and hence no VIIIR:AG released VIII:C only when serum, adsorbed serum or cryoprecipitate from rat plasma was added to the perfusate. Cycloheximide blocked the release of VIII:C from rat liver.

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Year:  1979        PMID: 315789     DOI: 10.1111/j.1365-2141.1979.tb03754.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN: 0007-1048            Impact factor:   6.998


  3 in total

1.  Factor VIII-East Hartford (arginine 1689 to cysteine) has procoagulant activity when separated from von Willebrand factor.

Authors:  A M Aly; L W Hoyer
Journal:  J Clin Invest       Date:  1992-05       Impact factor: 14.808

Review 2.  Perioperative management of patients with von Willebrand's disease.

Authors:  C B Cameron; N Kobrinsky
Journal:  Can J Anaesth       Date:  1990-04       Impact factor: 5.063

3.  Liver transplantation in hemophilia A.

Authors:  F A Bontempo; J H Lewis; T J Gorenc; J A Spero; M V Ragni; J P Scott; T E Starzl
Journal:  Blood       Date:  1987-06       Impact factor: 22.113

  3 in total

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