Literature DB >> 31577931

Substrates of PHD.

Frank S Lee1.   

Abstract

The discovery of prolyl hydroxylase domain proteins (PHDs) as key enzymes in the hypoxia inducible factor (HIF) pathway has been followed by reports of a multitude of non-HIF substrates of PHD. Reporting in eLife, Cockman et al. (2019) find a surprising lack of detectable PHD activity toward any of them.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Year:  2019        PMID： 31577931     DOI： 10.1016/j.cmet.2019.08.008

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  5 in total

1.  Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.

Authors:  Sang Bae Lee; Aram Ko; Young Taek Oh; Peiguo Shi; Fulvio D'Angelo; Brulinda Frangaj; Antonius Koller; Emily I Chen; Timothy Cardozo; Antonio Iavarone; Anna Lasorella
Journal:  Mol Cell       Date:  2020-07-07       Impact factor: 17.970

Review 2.  Cellular adaptation to hypoxia through hypoxia inducible factors and beyond.

Authors:  Pearl Lee; Navdeep S Chandel; M Celeste Simon
Journal:  Nat Rev Mol Cell Biol       Date:  2020-03-06       Impact factor: 94.444

Review 3.  Gene transcription and chromatin regulation in hypoxia.

Authors:  Michael Batie; Sonia Rocha
Journal:  Biochem Soc Trans       Date:  2020-06-30       Impact factor: 5.407

Review 4.  Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease.

Authors:  Xianyi Meng; Ben Wielockx; Martina Rauner; Aline Bozec
Journal:  Front Cell Dev Biol       Date:  2021-03-18

Review 5.  Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators.

Authors:  Sally C Fletcher; Mathew L Coleman
Journal:  Biochem Soc Trans       Date:  2020-10-30       Impact factor: 5.407
  5 in total

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