Literature DB >> 31576360

Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response.

Faustino Mollinedo1, Consuelo Gajate1.   

Abstract

Entities:  

Year:  2019        PMID： 31576360      PMCID： PMC6685885          DOI： 10.21037/atm.2019.06.40

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


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  54 in total

Review 1.  Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.

Authors:  Yu Cai; Jyothi Arikkath; Lu Yang; Ming-Lei Guo; Palsamy Periyasamy; Shilpa Buch
Journal:  Autophagy       Date:  2016       Impact factor: 16.016

Review 2.  Drugging RAS: Know the enemy.

Authors:  Bjoern Papke; Channing J Der
Journal:  Science       Date:  2017-03-16       Impact factor: 47.728

3.  Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.

Authors:  C Gajate; M Matos-da-Silva; el-H Dakir; R I Fonteriz; J Alvarez; F Mollinedo
Journal:  Oncogene       Date:  2011-11-07       Impact factor: 9.867

4.  ERK1/2 acts as a switch between necrotic and apoptotic cell death in ether phospholipid edelfosine-treated glioblastoma cells.

Authors:  Sara Melo-Lima; Maria C Lopes; Faustino Mollinedo
Journal:  Pharmacol Res       Date:  2015-03-06       Impact factor: 7.658

5.  Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.

Authors:  Tikvah K Hayes; Nicole F Neel; Chaoxin Hu; Prson Gautam; Melissa Chenard; Brian Long; Meraj Aziz; Michelle Kassner; Kirsten L Bryant; Mariaelena Pierobon; Raoud Marayati; Swapnil Kher; Samuel D George; Mai Xu; Andrea Wang-Gillam; Ahmed A Samatar; Anirban Maitra; Krister Wennerberg; Emanuel F Petricoin; Hongwei H Yin; Barry Nelkin; Adrienne D Cox; Jen Jen Yeh; Channing J Der
Journal:  Cancer Cell       Date:  2015-12-24       Impact factor: 31.743

6.  Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

Authors:  Andrea Viale; Piergiorgio Pettazzoni; Costas A Lyssiotis; Haoqiang Ying; Nora Sánchez; Matteo Marchesini; Alessandro Carugo; Tessa Green; Sahil Seth; Virginia Giuliani; Maria Kost-Alimova; Florian Muller; Simona Colla; Luigi Nezi; Giannicola Genovese; Angela K Deem; Avnish Kapoor; Wantong Yao; Emanuela Brunetto; Ya'an Kang; Min Yuan; John M Asara; Y Alan Wang; Timothy P Heffernan; Alec C Kimmelman; Huamin Wang; Jason B Fleming; Lewis C Cantley; Ronald A DePinho; Giulio F Draetta
Journal:  Nature       Date:  2014-08-10       Impact factor: 49.962

7.  DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.

Authors:  Yuchen Jiao; Chanjuan Shi; Barish H Edil; Roeland F de Wilde; David S Klimstra; Anirban Maitra; Richard D Schulick; Laura H Tang; Christopher L Wolfgang; Michael A Choti; Victor E Velculescu; Luis A Diaz; Bert Vogelstein; Kenneth W Kinzler; Ralph H Hruban; Nickolas Papadopoulos
Journal:  Science       Date:  2011-01-20       Impact factor: 47.728

8.  Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.

Authors:  Kirsten L Bryant; Clint A Stalnecker; Daniel Zeitouni; Jennifer E Klomp; Sen Peng; Andrey P Tikunov; Venugopal Gunda; Mariaelena Pierobon; Andrew M Waters; Samuel D George; Garima Tomar; Björn Papke; G Aaron Hobbs; Liang Yan; Tikvah K Hayes; J Nathaniel Diehl; Gennifer D Goode; Nina V Chaika; Yingxue Wang; Guo-Fang Zhang; Agnieszka K Witkiewicz; Erik S Knudsen; Emanuel F Petricoin; Pankaj K Singh; Jeffrey M Macdonald; Nhan L Tran; Costas A Lyssiotis; Haoqiang Ying; Alec C Kimmelman; Adrienne D Cox; Channing J Der
Journal:  Nat Med       Date:  2019-03-04       Impact factor: 53.440

9.  Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish.

Authors:  Chuan Yan; Xiaojing Huo; Shu Wang; Yi Feng; Zhiyuan Gong
Journal:  J Hepatol       Date:  2015-03-28       Impact factor: 25.083

Review 10.  Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors.

Authors:  Cynthia I Chude; Ravi K Amaravadi
Journal:  Int J Mol Sci       Date:  2017-06-16       Impact factor: 5.923
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  13 in total

Review 1.  Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy: Thematic Review Series: Biology of Lipid Rafts.

Authors:  Faustino Mollinedo; Consuelo Gajate
Journal:  J Lipid Res       Date:  2020-11-07       Impact factor: 5.922

Review 2.  Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy.

Authors:  Faustino Mollinedo; Consuelo Gajate
Journal:  J Lipid Res       Date:  2020-01-27       Impact factor: 5.922

Review 3.  Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?

Authors:  Moein Ala; Mahan Ala
Journal:  ACS Pharmacol Transl Sci       Date:  2021-11-01

4.  Exploration of the System-Level Mechanisms of the Herbal Drug FDY003 for Pancreatic Cancer Treatment: A Network Pharmacological Investigation.

Authors:  Ho-Sung Lee; In-Hee Lee; Kyungrae Kang; Sang-In Park; Minho Jung; Seung Gu Yang; Tae-Wook Kwon; Dae-Yeon Lee
Journal:  Evid Based Complement Alternat Med       Date:  2022-05-10       Impact factor: 2.650

5.  High Levels of miR-7-5p Potentiate Crizotinib-Induced Cytokilling and Autophagic Flux by Targeting RAF1 in NPM-ALK Positive Lymphoma Cells.

Authors:  Domenico Sorrentino; Julie Frentzel; Géraldine Mitou; Rafael B Blasco; Avédis Torossian; Coralie Hoareau-Aveilla; Chiara Pighi; Manon Farcé; Fabienne Meggetto; Stéphane Manenti; Estelle Espinos; Roberto Chiarle; Sylvie Giuriato
Journal:  Cancers (Basel)       Date:  2020-10-13       Impact factor: 6.639

6.  Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival.

Authors:  Yan Geng; Renguo Guan; Weifeng Hong; Bowen Huang; Peizhen Liu; Xiaohua Guo; Shixiong Hu; Min Yu; Baohua Hou
Journal:  Ann Transl Med       Date:  2020-03

7.  Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition.

Authors:  Consuelo Gajate; Odile Gayet; Nicolas A Fraunhoffer; Juan Iovanna; Nelson Dusetti; Faustino Mollinedo
Journal:  Cancers (Basel)       Date:  2021-12-05       Impact factor: 6.639

8.  Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release.

Authors:  Rósula García-Navas; Consuelo Gajate; Faustino Mollinedo
Journal:  Sci Rep       Date:  2021-06-15       Impact factor: 4.379

Review 9.  Autophagy and tumorigenesis.

Authors:  Michael Rangel; Jerry Kong; Vrushank Bhatt; Khoosheh Khayati; Jessie Yanxiang Guo
Journal:  FEBS J       Date:  2021-07-16       Impact factor: 5.542

10.  TLE2 is associated with favorable prognosis and regulates cell growth and gemcitabine sensitivity in pancreatic cancer.

Authors:  Shixiong Hu; Zhengbo Chen; Jinling Gu; Liyang Tan; Meifeng Zhang; Weidong Lin
Journal:  Ann Transl Med       Date:  2020-08
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