Literature DB >> 31576351

Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery.

Richard W Olsen1, A Kerstin Lindemeyer1, Martin Wallner1, Xiaorun Li2, Kevin W Huynh2, Z Hong Zhou2.   

Abstract

Year:  2019        PMID： 31576351      PMCID： PMC6685854          DOI： 10.21037/atm.2019.06.23

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


× No keyword cloud information.
  37 in total

1.  Key receptor involved in neuronal signalling visualized.

Authors:  Erwin Sigel
Journal:  Nature       Date:  2018-07       Impact factor: 49.962

2.  Alcohol selectivity of β3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the α+β- subunit interface in αβ3δ GABAA receptors.

Authors:  M Wallner; H J Hanchar; R W Olsen
Journal:  Neurochem Res       Date:  2014-02-06       Impact factor: 3.996

3.  Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.

Authors:  Zuzana Dostalova; Xiaojuan Zhou; Aiping Liu; Xi Zhang; Yinghui Zhang; Rooma Desai; Stuart A Forman; Keith W Miller
Journal:  Protein Sci       Date:  2013-12-16       Impact factor: 6.725

Review 4.  An Emerging Circuit Pharmacology of GABAA Receptors.

Authors:  Elif Engin; Rebecca S Benham; Uwe Rudolph
Journal:  Trends Pharmacol Sci       Date:  2018-06-11       Impact factor: 14.819

5.  The GABAA receptor alpha+beta- interface: a novel target for subtype selective drugs.

Authors:  Joachim Ramerstorfer; Roman Furtmüller; Isabella Sarto-Jackson; Zdravko Varagic; Werner Sieghart; Margot Ernst
Journal:  J Neurosci       Date:  2011-01-19       Impact factor: 6.167

6.  Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2.

Authors:  Scott B Hansen; Xiao Tao; Roderick MacKinnon
Journal:  Nature       Date:  2011-08-28       Impact factor: 49.962

Review 7.  Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranes.

Authors:  Nigel Unwin
Journal:  Q Rev Biophys       Date:  2013-09-20       Impact factor: 5.318

8.  Crystal structure of a human GABAA receptor.

Authors:  Paul S Miller; A Radu Aricescu
Journal:  Nature       Date:  2014-06-08       Impact factor: 49.962

9.  TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.

Authors:  Yuan Gao; Erhu Cao; David Julius; Yifan Cheng
Journal:  Nature       Date:  2016-05-18       Impact factor: 49.962

10.  GABAA receptor signalling mechanisms revealed by structural pharmacology.

Authors:  Simonas Masiulis; Rooma Desai; Tomasz Uchański; Itziar Serna Martin; Duncan Laverty; Dimple Karia; Tomas Malinauskas; Jasenko Zivanov; Els Pardon; Abhay Kotecha; Jan Steyaert; Keith W Miller; A Radu Aricescu
Journal:  Nature       Date:  2019-01-02       Impact factor: 49.962
View more
  2 in total

1.  The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABAA receptor.

Authors:  Brandon Pressly; Ruth D Lee; Vikrant Singh; Isaac N Pessah; Heike Wulff
Journal:  Ann Clin Transl Neurol       Date:  2022-03-24       Impact factor: 5.430

2.  Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the α 2 β 3 γ 2 GABAA Receptor.

Authors:  Brandon Pressly; Ruth D Lee; Bogdan Barnych; Bruce D Hammock; Heike Wulff
Journal:  Mol Pharmacol       Date:  2020-10-27       Impact factor: 4.054
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.