Literature DB >> 31574415

LIN28: A cancer stem cell promoter for immunotherapy in head and neck squamous cell carcinoma.

Mengxue Li1, Heng Chen1, Tianfu Wu2.   

Abstract

Lin28, a highly conserved RNA-binding protein, plays an important role in differentiation, metabolism, proliferation, pluripotency, and tumourigenicity. Lin28 overexpression promotes tumour-cell proliferation and metastasis in various human cancers, including head and neck cancer. Multiple studies demonstrate that Lin28 critically contributes to anti-tumour immunity and production of cancer stem cells in head and neck squamous cell carcinoma (HNSCC). Thus, Lin28 has potential application in HNSCC treatment.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cancer stem cell; Cell reprogramming; Development; Head and neck cancer; Immunotherapy; Lin28; Lin28/let-7; PD-L1; Squamous cell carcinoma; Stem cell therapy

Mesh：

Substances：

Year:  2019        PMID： 31574415     DOI： 10.1016/j.oraloncology.2019.09.024

Source DB:  PubMed          Journal:  Oral Oncol        ISSN： 1368-8375            Impact factor:   5.337


  3 in total

Review 1.  RNA-binding proteins in tumor progression.

Authors:  Hai Qin; Haiwei Ni; Yichen Liu; Yaqin Yuan; Tao Xi; Xiaoman Li; Lufeng Zheng
Journal:  J Hematol Oncol       Date:  2020-07-11       Impact factor: 17.388

Review 2.  RNA-Binding Proteins as Regulators of Migration, Invasion and Metastasis in Oral Squamous Cell Carcinoma.

Authors:  Jonas Weiße; Julia Rosemann; Vanessa Krauspe; Matthias Kappler; Alexander W Eckert; Monika Haemmerle; Tony Gutschner
Journal:  Int J Mol Sci       Date:  2020-09-17       Impact factor: 5.923

3.  RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7.

Authors:  Hailin Zou; Juan Luo; Yibo Guo; Yuhong Liu; Yun Wang; Liang Deng; Peng Li
Journal:  Oncogene       Date:  2022-01-31       Impact factor: 8.756
  3 in total

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