Yong Zhao1, Chuanyu Dai2, Zheng Wang1, Weimin Chen1, Jiaguo Liu3, Renxi Zhuo2, Aixi Yu1, Shiwen Huang2. 1. Department of Orthopedic Trauma and Microsurgy, Zhongnan Hospital of Wuhan University, Wuhan 430070, Hubei, People's Republic of China. 2. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, People's Republic of China. 3. Department of Orthopedics, Hubei University of Medicine Affliated Taihe Hospital, Shiyan 442000, Hubei, People's Republic of China.
Abstract
PURPOSE: To prepare a novel wound dressing to facilitate cutaneous wound healing. METHODS: Curcumin (Cur) was added to the ring-shaped β-cyclodextrin (CD) to form a β-CD-Cur inclusion complex (CD-Cur). CD-Cur was then integrated into a composite chitosan-alginate (CA) mix. Finally, CA-CD-Cur was generated with a freeze-drying technique. Water-uptake capacity, degradation rate, and drug-release kinetics of the newly formed dressing were investigated in vitro. In animal studies, cutaneous wounds in rats were created, treated with CA-CD-Cur, then compared to CA-Cur, CA, and gauze. RESULTS: CA-CD-Cur-treated wounds showed accelerated closure rates, improved histopathological results, and lower SOD, lipid peroxidation, pI3K, and pAktkt levels than other groups. On the contrary, catalase, IκBα, and TGFβ1 levels were higher than others. CONCLUSION: CA-CD-Cur may facilitate cutaneous wound dressing that facilitate wound healing.
PURPOSE: To prepare a novel wound dressing to facilitate cutaneous wound healing. METHODS: Curcumin (Cur) was added to the ring-shaped β-cyclodextrin (CD) to form a β-CD-Cur inclusion complex (CD-Cur). CD-Cur was then integrated into a composite chitosan-alginate (CA) mix. Finally, CA-CD-Cur was generated with a freeze-drying technique. Water-uptake capacity, degradation rate, and drug-release kinetics of the newly formed dressing were investigated in vitro. In animal studies, cutaneous wounds in rats were created, treated with CA-CD-Cur, then compared to CA-Cur, CA, and gauze. RESULTS: CA-CD-Cur-treated wounds showed accelerated closure rates, improved histopathological results, and lower SOD, lipid peroxidation, pI3K, and pAktkt levels than other groups. On the contrary, catalase, IκBα, and TGFβ1 levels were higher than others. CONCLUSION: CA-CD-Cur may facilitate cutaneous wound dressing that facilitate wound healing.
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