Literature DB >> 31570815

Clarifying the function of genes at the chromosome 16p13 locus in type 1 diabetes: CLEC16A and DEXI.

Morgan A Gingerich1, Vaibhav Sidarala1, Scott A Soleimanpour2,3.   

Abstract

More than a decade after the discovery of a novel type 1 diabetes risk locus on chromosome 16p13, there remains complexity and controversy over the specific gene(s) that regulate diabetes pathogenesis. A new study by Nieves-Bonilla et al. shows that one of these genes, DEXI, is unlikely to contribute to type 1 diabetes pathogenesis and positions the endolysosomal E3 ubiquitin ligase CLEC16A as the primary culprit by which this gene locus influences diabetes risk.

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Year:  2019        PMID： 31570815      PMCID： PMC7108966          DOI： 10.1038/s41435-019-0087-7

Source DB:  PubMed          Journal:  Genes Immun        ISSN： 1466-4879            Impact factor:   2.676


  23 in total

1.  Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.

Authors:  I-L Mero; M Ban; Å R Lorentzen; C Smestad; E G Celius; H Sæther; H Saeedi; M K Viken; B Skinningsrud; D E Undlien; J Aarseth; K-M Myhr; S Granum; A Spurkland; S Sawcer; A Compston; B A Lie; H F Harbo
Journal:  Genes Immun       Date:  2010-12-23       Impact factor: 2.676

2.  A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

Authors:  Hakon Hakonarson; Struan F A Grant; Jonathan P Bradfield; Luc Marchand; Cecilia E Kim; Joseph T Glessner; Rosemarie Grabs; Tracy Casalunovo; Shayne P Taback; Edward C Frackelton; Margaret L Lawson; Luke J Robinson; Robert Skraban; Yang Lu; Rosetta M Chiavacci; Charles A Stanley; Susan E Kirsch; Eric F Rappaport; Jordan S Orange; Dimitri S Monos; Marcella Devoto; Hui-Qi Qu; Constantin Polychronakos
Journal:  Nature       Date:  2007-07-15       Impact factor: 49.962

Review 3.  Genetics of type 1A diabetes.

Authors:  Patrick Concannon; Stephen S Rich; Gerald T Nepom
Journal:  N Engl J Med       Date:  2009-04-16       Impact factor: 91.245

4.  The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection.

Authors:  Cornelia Schuster; Kay D Gerold; Kilian Schober; Lilli Probst; Kevin Boerner; Mi-Jeong Kim; Anna Ruckdeschel; Thomas Serwold; Stephan Kissler
Journal:  Immunity       Date:  2015-05-12       Impact factor: 31.745

5.  Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema.

Authors:  A J Edgar; E J Birks; M H Yacoub; J M Polak
Journal:  Am J Respir Cell Mol Biol       Date:  2001-07       Impact factor: 6.914

6.  DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway.

Authors:  Reinaldo S Dos Santos; Laura Marroqui; Teresa Velayos; Ane Olazagoitia-Garmendia; Amaia Jauregi-Miguel; Ainara Castellanos-Rubio; Decio L Eizirik; Luis Castaño; Izortze Santin
Journal:  Diabetologia       Date:  2018-11-26       Impact factor: 10.122

7.  Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells.

Authors:  Ingvild S Leikfoss; Pankaj K Keshari; Marte W Gustavsen; Anja Bjølgerud; Ina S Brorson; Elisabeth G Celius; Anne Spurkland; Steffan D Bos; Hanne F Harbo; Tone Berge
Journal:  PLoS One       Date:  2015-07-23       Impact factor: 3.240

8.  Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates β-Cell Mitophagy.

Authors:  Gemma Pearson; Biaoxin Chai; Tracy Vozheiko; Xueying Liu; Malathi Kandarpa; Robert C Piper; Scott A Soleimanpour
Journal:  Diabetes       Date:  2017-11-27       Impact factor: 9.337

9.  GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans.

Authors:  Jianhua Yin; Yaling Huang; Pengfei Guo; Siqi Hu; Sawako Yoshina; Nan Xuan; Qiwen Gan; Shohei Mitani; Chonglin Yang; Xiaochen Wang
Journal:  J Cell Biol       Date:  2017-04-19       Impact factor: 10.539

10.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Authors: 
Journal:  Nature       Date:  2007-06-07       Impact factor: 49.962
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  5 in total

Review 1.  A Selective Look at Autophagy in Pancreatic β-Cells.

Authors:  Gemma L Pearson; Morgan A Gingerich; Emily M Walker; Trevor J Biden; Scott A Soleimanpour
Journal:  Diabetes       Date:  2021-05-20       Impact factor: 9.337

2.  Mitophagy protects β cells from inflammatory damage in diabetes.

Authors:  Vaibhav Sidarala; Gemma L Pearson; Vishal S Parekh; Benjamin Thompson; Lisa Christen; Morgan A Gingerich; Jie Zhu; Tracy Stromer; Jianhua Ren; Emma C Reck; Biaoxin Chai; John A Corbett; Thomas Mandrup-Poulsen; Leslie S Satin; Scott A Soleimanpour
Journal:  JCI Insight       Date:  2020-12-17

Review 3.  Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction.

Authors:  Alberto Bartolomé
Journal:  Int J Mol Sci       Date:  2022-01-02       Impact factor: 5.923

4.  Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes.

Authors:  Lucas H Armitage; Scott E Stimpson; Katherine E Santostefano; Lina Sui; Similoluwa Ogundare; Brittney N Newby; Roberto Castro-Gutierrez; Mollie K Huber; Jared P Taylor; Prerana Sharma; Ilian A Radichev; Daniel J Perry; Natalie C Fredette; Alexei Y Savinov; Mark A Wallet; Naohiro Terada; Todd M Brusko; Holger A Russ; Jing Chen; Dieter Egli; Clayton E Mathews
Journal:  Front Endocrinol (Lausanne)       Date:  2021-11-09       Impact factor: 6.055

Review 5.  Advances in Knowledge of Candidate Genes Acting at the Beta-Cell Level in the Pathogenesis of T1DM.

Authors:  Haipeng Pang; Shuoming Luo; Gan Huang; Ying Xia; Zhiguo Xie; Zhiguang Zhou
Journal:  Front Endocrinol (Lausanne)       Date:  2020-03-12       Impact factor: 5.555
  5 in total

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