Ashish Sharma1, Baruch D Kuppermann2, Francesco Bandello3, Paolo Lanzetta4, Dinah Zur5, Sung Wook Park6,7, Hyeong Gon Yu6, V R Saravanan8, Leandro Cabral Zacharias9, Alan K Barreira9, Matias Iglicki10, Fernando Miassi11, Daniele Veritti4, Sean Tsao2, Deepika Makam12, Nidhee Jain8, Anat Loewenstein5. 1. Lotus Eye Hospital and Institute, Avinashi Road, Coimbatore, TN, India. drashish79@hotmail.com. 2. Gavin Herbert Eye Institute at the University of California, Irvine, CA, USA. 3. University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy. 4. Department of Ophthalmology, University of Udine, Udine, Italy. 5. Division of Ophthalmology, Tel Aviv Sourasky Medical Center And Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 6. Department of Ophthalmology, Seoul National University Hospital, Seoul, 03080, Republic of Korea. 7. Seran Eye Center, Seoul, 06167, Republic of Korea. 8. Department of Vitreoretina, Aravind Eye Hospital, Coimbatore, TN, India. 9. University of Sao Paulo Medical School Allan Kardec Barreira: Attending- University of Sao Paulo; Medical Director- HCLOE Eye Hospital, Sao Paulo, Brazil. 10. Private Retina Service. University of Buenos Aires, Buenos Aires, Argentina. 11. Rosario Retina Clinic, Rosario, Argentina. 12. Lotus Eye Hospital and Institute, Avinashi Road, Coimbatore, TN, India.
Abstract
PURPOSE: To analyse the intraocular pressure rise after intravitreal dexamethasone implant (Ozurdex) amongst different geographic populations. METHODS: The medical charts of 294 dexamethasone implants between February 2011 and 2017 were reviewed retrospectively. South Asian (India), White (Europe, US and Israel) Latino (Argentina and Brazil) patient data was included in the study. Ocular hypertension (OHT) was defined as intraocular pressure of >25 mmHg or an increase of at least 10 mmHg from baseline. The main indications for treatment were diabetic macular edema (ME) (65.6%), retinal vein occlusion (26.5%), uveitis (7.8%). RESULTS: Amongst 294 intravitreal implants, ocular hypertension (>25 mmHg) was recorded in 0, 8 and 9.5% in White, Latino, and South Asian groups, respectively. However, IOP > 20 mmHg was recorded in 14%, 28% and 27% in White, Latino, and South Asian groups, respectively. Incidence of very high IOP (>35 mmHg) was lower in all geographical groups. It was 3% in Latino followed by 2% in South Asian group. CONCLUSION: Latino and South Asian groups have higher IOP rise compared to White population. Most patients with elevated IOP fluctuate between 20-25 mmHg.
PURPOSE: To analyse the intraocular pressure rise after intravitreal dexamethasone implant (Ozurdex) amongst different geographic populations. METHODS: The medical charts of 294 dexamethasone implants between February 2011 and 2017 were reviewed retrospectively. South Asian (India), White (Europe, US and Israel) Latino (Argentina and Brazil) patient data was included in the study. Ocular hypertension (OHT) was defined as intraocular pressure of >25 mmHg or an increase of at least 10 mmHg from baseline. The main indications for treatment were diabetic macular edema (ME) (65.6%), retinal vein occlusion (26.5%), uveitis (7.8%). RESULTS: Amongst 294 intravitreal implants, ocular hypertension (>25 mmHg) was recorded in 0, 8 and 9.5% in White, Latino, and South Asian groups, respectively. However, IOP > 20 mmHg was recorded in 14%, 28% and 27% in White, Latino, and South Asian groups, respectively. Incidence of very high IOP (>35 mmHg) was lower in all geographical groups. It was 3% in Latino followed by 2% in South Asian group. CONCLUSION: Latino and South Asian groups have higher IOP rise compared to White population. Most patients with elevated IOP fluctuate between 20-25 mmHg.
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