Jhe-Cyuan Guo1,2,3, Chia-Chi Lin1,2, Chen-Yuan Lin4, Min-Shu Hsieh5, Hung-Yang Kuo1,6, Ming-Yu Lien4, Yu-Yun Shao1,3,6, Ta-Chen Huang7,6, Chih-Hung Hsu7,3,6. 1. Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, R.O.C. 2. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, R.O.C. 3. Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan, R.O.C. 4. Division of Hematology and Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C. 5. Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan, R.O.C. 6. Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan, R.O.C. 7. Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, R.O.C. e360215@gmail.com chihhunghsu@ntu.edu.tw.
Abstract
BACKGROUND/AIM: This study explored the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) and use of antibiotics in advanced esophageal squamous cell carcinoma (ESCC) patients receiving immune checkpoint inhibitors (ICIs). PATIENTS AND METHODS: Patients were enrolled from two referral centers in Taiwan. Clinical benefit was defined as complete response, partial response, or a stable disease for ≥6 months via Response Evaluation Criteria In Solid Tumors 1.1. Clinicopathological factors' impact on overall survival (OS) and progression-free survival (PFS) was analyzed via Cox proportional hazards model. RESULTS: Forty-nine patients were enrolled. The median PFS and OS were 1.8 and 6.1 months, respectively. The median NLR at baseline was 6.40, and 21 patients received antibiotics. Both high NLR and use of antibiotics were associated with inferior PFS (p=0.028 and p<0.001, respectively) and OS (p<0.001 and p<0.001, respectively) in multivariate analysis. CONCLUSION: High NLR and use of antibiotics were associated with inferior survival in advanced ESCC patients receiving ICIs. Copyright
BACKGROUND/AIM: This study explored the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) and use of antibiotics in advanced esophageal squamous cell carcinoma (ESCC) patients receiving immune checkpoint inhibitors (ICIs). PATIENTS AND METHODS: Patients were enrolled from two referral centers in Taiwan. Clinical benefit was defined as complete response, partial response, or a stable disease for ≥6 months via Response Evaluation Criteria In Solid Tumors 1.1. Clinicopathological factors' impact on overall survival (OS) and progression-free survival (PFS) was analyzed via Cox proportional hazards model. RESULTS: Forty-nine patients were enrolled. The median PFS and OS were 1.8 and 6.1 months, respectively. The median NLR at baseline was 6.40, and 21 patients received antibiotics. Both high NLR and use of antibiotics were associated with inferior PFS (p=0.028 and p<0.001, respectively) and OS (p<0.001 and p<0.001, respectively) in multivariate analysis. CONCLUSION: High NLR and use of antibiotics were associated with inferior survival in advanced ESCCpatients receiving ICIs. Copyright